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. 1971 Sep;64(3):575–584.

Elevated Plasma Activity of Lactate Dehydrogenase Isoenzyme-3 (LDH3) in Experimentally Induced Immunologic Lung Injury

J E Hagadorn, C M Bloor, M S Yang
PMCID: PMC2047622  PMID: 5133518

Abstract

Normal rats injected intravenously with rabbit antiserum to rat lung develop acute pulmonary lesions characterized by an altered vascular permeability. In the present study, an increase in plasma LDH3 activity is shown to be positively correlated with the different levels of circulating antilung antibodies and with the morphologic severity of lung injury elicited by these pathogenic immunoglobulins. Within 24 hours, the acute lung changes are resolved, accompanied by a return of the activities of plasma LDH isoenzymes to normal. It is proposed that the plasma LDH3 isoenzymes are released into the circulation from injured alveolar capillary endothelial cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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