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. 1992 Jan;174(1):320–323. doi: 10.1128/jb.174.1.320-323.1992

In vivo inhibition of TonB-dependent processes by a TonB box consensus pentapeptide.

M Tuckman 1, M S Osburne 1
PMCID: PMC205712  PMID: 1729219

Abstract

The TonB box, a conserved pentapeptide sequence found in TonB-dependent colicins and receptors, is thought to interact physically with the TonB protein to facilitate TonB-dependent processes. Strains of Escherichia coli were treated in vivo with the synthetic TonB box pentapeptide Glu-Thr-Val-Ile-Val. The pentapeptide inhibited several TonB-dependent processes, including cell growth in low-iron medium, phi 80 infection, and killing by colicins B and Ia. Two unrelated control pentapeptides had no effect on TonB-dependent processes.

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Selected References

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