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. 1998 Nov;78(9):1224–1232. doi: 10.1038/bjc.1998.659

Cancer mortality in relation to monitoring for radionuclide exposure in three UK nuclear industry workforces.

L M Carpenter 1, C D Higgins 1, A J Douglas 1, N E Maconochie 1, R Z Omar 1, P Fraser 1, V Beral 1, P G Smith 1
PMCID: PMC2063005  PMID: 9820185

Abstract

Cancer mortality in 40,761 employees of three UK nuclear industry facilities who had been monitored for external radiation exposure was examined according to whether they had also been monitored for possible internal exposure to tritium, plutonium or other radionuclides (uranium, polonium, actinium or other unspecified). Death rates from cancer were compared both with national rates and with rates in radiation workers not monitored for exposure to any radionuclides. Among workers monitored for tritium exposure, overall cancer mortality was significantly below national rates [standardized mortality ratio (SMR) = 83, 165 deaths; 2P = 0.02] and none of the cancer-specific death rates was significantly above either the national average or rates in non-monitored workers. Although the overall death rate from cancer in workers monitored for plutonium exposure was also significantly low relative to national rates (SMR = 89, 581 deaths; 2P = 0.005), mortality from pleural cancer was significantly raised (SMR = 357, nine deaths; 2P = 0.002); none of the rates differed significantly from those of non-monitored workers. Workers monitored for radionuclides other than tritium or plutonium also had a death rate from all cancers combined that was below the national average (SMR = 86, 418 deaths; 2P = 0.002) but prostatic cancer mortality was raised both in relation to death rates in the general population (SMR = 153, 37 deaths; 2P = 0.02) and to death rates in radiation workers who had not been monitored for exposure to any radionuclide [rate ratio (RR) = 1.65; 2P = 0.03]. Mortality from cancer of the lung was also significantly increased in workers monitored for other radionuclides compared with those of radiation workers not monitored for exposure to radionuclides (RR = 1.31, 164 deaths; 2P = 0.01). For cancers of the lung, prostate and all cancers combined, death rates in monitored workers were examined according to the timing and duration of monitoring for radionuclide exposure, with rates of radiation workers not monitored for any radionuclide forming the comparison group. In tritium-monitored workers, RRs for prostatic cancer varied significantly according to the number of years in which they were monitored (2P = 0.03). In workers monitored for plutonium exposure, RRs for all cancers combined increased with the number of years in which they were monitored (2P = 0.04) and with the number of years since first monitoring (2P = 0.0003). There was little suggestion of systematic variation in RRs for workers monitored for other radionuclides in relation to the timing or duration of monitoring, nor did it appear that their raised rates of cancer of the lung and prostate were explained by external radiation dose. These analyses of cancer mortality in relation to monitoring for radionuclide exposure reported in a large cohort of nuclear industry workers suggest that certain patterns of monitoring for some radionuclides may be associated with higher death rates from cancers of the lung, pleura, prostate and all cancers combined. Some of these findings may be due to chance. Moreover, because of the paucity of related data and lack of information about other possible exposures, such as whether plutonium workers are more likely to be exposed to asbestos, firm conclusions cannot be drawn at this stage. Further investigations of the relationship between radionuclide exposure and cancer in nuclear industry workers are needed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beral V., Fraser P., Carpenter L., Booth M., Brown A., Rose G. Mortality of employees of the Atomic Weapons Establishment, 1951-82. BMJ. 1988 Sep 24;297(6651):757–770. doi: 10.1136/bmj.297.6651.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beral V., Inskip H., Fraser P., Booth M., Coleman D., Rose G. Mortality of employees of the United Kingdom Atomic Energy Authority, 1946-1979. Br Med J (Clin Res Ed) 1985 Aug 17;291(6493):440–447. doi: 10.1136/bmj.291.6493.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cardis E., Gilbert E. S., Carpenter L., Howe G., Kato I., Armstrong B. K., Beral V., Cowper G., Douglas A., Fix J. Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat Res. 1995 May;142(2):117–132. [PubMed] [Google Scholar]
  4. Carpenter L., Higgins C., Douglas A., Fraser P., Beral V., Smith P. Combined analysis of mortality in three United Kingdom nuclear industry workforces, 1946-1988. Radiat Res. 1994 May;138(2):224–238. [PubMed] [Google Scholar]
  5. Checkoway H., Pearce N., Crawford-Brown D. J., Cragle D. L. Radiation doses and cause-specific mortality among workers at a nuclear materials fabrication plant. Am J Epidemiol. 1988 Feb;127(2):255–266. doi: 10.1093/oxfordjournals.aje.a114801. [DOI] [PubMed] [Google Scholar]
  6. Douglas A. J., Omar R. Z., Smith P. G. Cancer mortality and morbidity among workers at the Sellafield plant of British Nuclear Fuels. Br J Cancer. 1994 Dec;70(6):1232–1243. doi: 10.1038/bjc.1994.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fraser P., Booth M., Beral V., Inskip H., Firsht S., Speak S. Collection and validation of data in the United Kingdom Atomic Energy Authority mortality study. Br Med J (Clin Res Ed) 1985 Aug 17;291(6493):435–439. doi: 10.1136/bmj.291.6493.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fraser P., Carpenter L., Maconochie N., Higgins C., Booth M., Beral V. Cancer mortality and morbidity in employees of the United Kingdom Atomic Energy Authority, 1946-86. Br J Cancer. 1993 Mar;67(3):615–624. doi: 10.1038/bjc.1993.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gilbert E. S., Cragle D. L., Wiggs L. D. Updated analyses of combined mortality data for workers at the Hanford Site, Oak Ridge National Laboratory, and Rocky Flats Weapons Plant. Radiat Res. 1993 Dec;136(3):408–421. [PubMed] [Google Scholar]
  10. Gilbert E. S., Petersen G. R., Buchanan J. A. Mortality of workers at the Hanford site: 1945-1981. Health Phys. 1989 Jan;56(1):11–25. doi: 10.1097/00004032-198901000-00001. [DOI] [PubMed] [Google Scholar]
  11. Inskip H., Beral V., Fraser P., Booth M., Coleman D., Brown A. Further assessment of the effects of occupational radiation exposure in the United Kingdom Atomic Energy Authority mortality study. Br J Ind Med. 1987 Mar;44(3):149–160. doi: 10.1136/oem.44.3.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kendall G. M., Muirhead C. R., MacGibbon B. H., O'Hagan J. A., Conquest A. J., Goodill A. A., Butland B. K., Fell T. P., Jackson D. A., Webb M. A. Mortality and occupational exposure to radiation: first analysis of the National Registry for Radiation Workers. BMJ. 1992 Jan 25;304(6821):220–225. doi: 10.1136/bmj.304.6821.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lubin J. H., Boice J. D., Jr, Edling C., Hornung R. W., Howe G. R., Kunz E., Kusiak R. A., Morrison H. I., Radford E. P., Samet J. M. Lung cancer in radon-exposed miners and estimation of risk from indoor exposure. J Natl Cancer Inst. 1995 Jun 7;87(11):817–827. doi: 10.1093/jnci/87.11.817. [DOI] [PubMed] [Google Scholar]
  14. Rooney C., Beral V., Maconochie N., Fraser P., Davies G. Case-control study of prostatic cancer in employees of the United Kingdom Atomic Energy Authority. BMJ. 1993 Nov 27;307(6916):1391–1397. doi: 10.1136/bmj.307.6916.1391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Smith P. G., Douglas A. J. Mortality of workers at the Sellafield plant of British Nuclear Fuels. Br Med J (Clin Res Ed) 1986 Oct 4;293(6551):845–854. doi: 10.1136/bmj.293.6551.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Wilkinson G. S., Tietjen G. L., Wiggs L. D., Galke W. A., Acquavella J. F., Reyes M., Voelz G. L., Waxweiler R. J. Mortality among plutonium and other radiation workers at a plutonium weapons facility. Am J Epidemiol. 1987 Feb;125(2):231–250. doi: 10.1093/oxfordjournals.aje.a114523. [DOI] [PubMed] [Google Scholar]
  17. Wing S., Shy C. M., Wood J. L., Wolf S., Cragle D. L., Frome E. L. Mortality among workers at Oak Ridge National Laboratory. Evidence of radiation effects in follow-up through 1984. JAMA. 1991 Mar 20;265(11):1397–1402. [PubMed] [Google Scholar]

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