Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1997;75(2):264–267. doi: 10.1038/bjc.1997.43

Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.

A Iida 1, R Isobe 1, M Yoshimoto 1, F Kasumi 1, Y Nakamura 1, M Emi 1
PMCID: PMC2063259  PMID: 9010036

Abstract

Allelic losses on chromosome 16q in tumour cells are frequent in a variety of malignancies, suggesting the presence of one or more tumour-suppressor genes in the region. Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for at least one locus was lost in 141 (67%). Detailed deletion mapping revealed two distinct commonly deleted regions. One region was defined as a 3-cM interval flanked by markers D16S512 and D16S515 at 16q22; the second consisted of a 9.5-cM interval flanked by markers D16S498 and D16S303 at q24.3. Allelic loss on 16q was observed frequently in small tumours, tumours without lymph node metastasis and tumours of the non-invasive histological type as well as in tumours of more advanced phenotype, suggesting that inactivation of one of at least two tumour-suppressor genes on 16q plays a role in early stage breast carcinogenesis.

Full text

PDF
264

Images in this article

265Figure 1
on p.265

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Callen D. F., Lane S. A., Kozman H., Kremmidiotis G., Whitmore S. A., Lowenstein M., Doggett N. A., Kenmochi N., Page D. C., Maglott D. R. Integration of transcript and genetic maps of chromosome 16 at near-1-Mb resolution: demonstration of a "hot spot" for recombination at 16p12. Genomics. 1995 Sep 20;29(2):503–511. doi: 10.1006/geno.1995.9005. [DOI] [PubMed] [Google Scholar]
  2. Carter B. S., Ewing C. M., Ward W. S., Treiger B. F., Aalders T. W., Schalken J. A., Epstein J. I., Isaacs W. B. Allelic loss of chromosomes 16q and 10q in human prostate cancer. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8751–8755. doi: 10.1073/pnas.87.22.8751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cleton-Jansen A. M., Moerland E. W., Kuipers-Dijkshoorn N. J., Callen D. F., Sutherland G. R., Hansen B., Devilee P., Cornelisse C. J. At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer. Genes Chromosomes Cancer. 1994 Feb;9(2):101–107. doi: 10.1002/gcc.2870090205. [DOI] [PubMed] [Google Scholar]
  4. Durocher F., Morissette J., Labrie Y., Labrie F., Simard J. Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2. Genomics. 1995 Feb 10;25(3):724–726. doi: 10.1016/0888-7543(95)80017-g. [DOI] [PubMed] [Google Scholar]
  5. Gyapay G., Morissette J., Vignal A., Dib C., Fizames C., Millasseau P., Marc S., Bernardi G., Lathrop M., Weissenbach J. The 1993-94 Généthon human genetic linkage map. Nat Genet. 1994 Jun;7(2 Spec No):246–339. doi: 10.1038/ng0694supp-246. [DOI] [PubMed] [Google Scholar]
  6. Harada Y., Katagiri T., Ito I., Akiyama F., Sakamoto G., Kasumi F., Nakamura Y., Emi M. Genetic studies of 457 breast cancers. Clinicopathologic parameters compared with genetic alterations. Cancer. 1994 Oct 15;74(8):2281–2286. doi: 10.1002/1097-0142(19941015)74:8<2281::aid-cncr2820740812>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  7. Ito I., Yoshimoto M., Iwase T., Watanabe S., Katagiri T., Harada Y., Kasumi F., Yasuda S., Mitomi T., Emi M. Association of genetic alterations on chromosome 17 and loss of hormone receptors in breast cancer. Br J Cancer. 1995 Mar;71(3):438–441. doi: 10.1038/bjc.1995.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kanai Y., Oda T., Tsuda H., Ochiai A., Hirohashi S. Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast. Jpn J Cancer Res. 1994 Oct;85(10):1035–1039. doi: 10.1111/j.1349-7006.1994.tb02902.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kozman H. M., Keith T. P., Donis-Keller H., White R. L., Weissenbach J., Dean M., Vergnaud G., Kidd K., Gusella J., Royle N. J. The CEPH consortium linkage map of human chromosome 16. Genomics. 1995 Jan 1;25(1):44–58. doi: 10.1016/0888-7543(95)80108-x. [DOI] [PubMed] [Google Scholar]
  10. Radford D. M., Fair K. L., Phillips N. J., Ritter J. H., Steinbrueck T., Holt M. S., Donis-Keller H. Allelotyping of ductal carcinoma in situ of the breast: deletion of loci on 8p, 13q, 16q, 17p and 17q. Cancer Res. 1995 Aug 1;55(15):3399–3405. [PubMed] [Google Scholar]
  11. Saito H., Inazawa J., Saito S., Kasumi F., Koi S., Sagae S., Kudo R., Saito J., Noda K., Nakamura Y. Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM region on 17q21.3 often and commonly deleted in tumors. Cancer Res. 1993 Jul 15;53(14):3382–3385. [PubMed] [Google Scholar]
  12. Sato T., Akiyama F., Sakamoto G., Kasumi F., Nakamura Y. Accumulation of genetic alterations and progression of primary breast cancer. Cancer Res. 1991 Nov 1;51(21):5794–5799. [PubMed] [Google Scholar]
  13. Sato T., Tanigami A., Yamakawa K., Akiyama F., Kasumi F., Sakamoto G., Nakamura Y. Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res. 1990 Nov 15;50(22):7184–7189. [PubMed] [Google Scholar]
  14. Skirnisdottir S., Eiriksdottir G., Baldursson T., Barkardottir R. B., Egilsson V., Ingvarrson S. High frequency of allelic imbalance at chromosome region 16q22-23 in human breast cancer: correlation with high PgR and low S phase. Int J Cancer. 1995 Apr 21;64(2):112–116. doi: 10.1002/ijc.2910640207. [DOI] [PubMed] [Google Scholar]
  15. Takita K., Sato T., Miyagi M., Watatani M., Akiyama F., Sakamoto G., Kasumi F., Abe R., Nakamura Y. Correlation of loss of alleles on the short arms of chromosomes 11 and 17 with metastasis of primary breast cancer to lymph nodes. Cancer Res. 1992 Jul 15;52(14):3914–3917. [PubMed] [Google Scholar]
  16. Thompson A. D., Shen Y., Holman K., Sutherland G. R., Callen D. F., Richards R. I. Isolation and characterisation of (AC)n microsatellite genetic markers from human chromosome 16. Genomics. 1992 Jun;13(2):402–408. doi: 10.1016/0888-7543(92)90260-y. [DOI] [PubMed] [Google Scholar]
  17. Tsuda H., Callen D. F., Fukutomi T., Nakamura Y., Hirohashi S. Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread. Cancer Res. 1994 Jan 15;54(2):513–517. [PubMed] [Google Scholar]
  18. Tsuda H., Hirohashi S. Identification of multiple breast cancers of multicentric origin by histological observations and distribution of allele loss on chromosome 16q. Cancer Res. 1995 Aug 1;55(15):3395–3398. [PubMed] [Google Scholar]
  19. Tsuda H., Zhang W. D., Shimosato Y., Yokota J., Terada M., Sugimura T., Miyamura T., Hirohashi S. Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6791–6794. doi: 10.1073/pnas.87.17.6791. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES