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. 1997;75(4):545–547. doi: 10.1038/bjc.1997.95

Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.

M M Kennedy 1, D Lamb 1, G King 1, K M Kerr 1
PMCID: PMC2063319  PMID: 9052408

Abstract

Immunohistochemical staining of bcl-2 and p53 proteins was compared with thymidine labelling index (TLI) and cell loss factor (O) in lung cancer. Neither bcl-2 nor p53 overexpression was associated with high cell loss but strong bcl-2 staining was associated with higher TLI. Concomitant strong p53 and bcl-2 expression, not the usual inverse relationship, plus high cell-loss factor was present in three neuroendocrine carcinomas. Other factors presumably have a role in controlling cell death in these tumours.

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Selected References

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