Skip to main content
PMC home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1993 Nov;175(22):7138–7141. doi: 10.1128/jb.175.22.7138-7141.1993

Conditional synthesis and utilization of 1,5-anhydroglucitol in Escherichia coli.

Y Shiga 1, H Mizuno 1, H Akanuma 1
PMCID: PMC206854  PMID: 8226660

Abstract

A cyclic polyol, 1,5-anhydro-D-glucitol (AG), is widely detected in most organisms, although little is known about its metabolism and physiological roles. The present study demonstrates the synthesis of AG in Escherichia coli C600. The major portion of the synthesized AG was indicated to be derived from glucose retaining all the six carbon atoms, and only 5% was attributed to AG synthesized from C3 compounds. AG synthesis is apparent in an early stage of the stationary phase, and accumulation is transient both in cells and in medium. Evidence is also presented for AG uptake and metabolism and for effects of cyclic AMP.

Full text

PDF
7139

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akanuma H., Ogawa K., Lee Y., Akanuma Y. Reduced levels of plasma 1,5-anhydroglucitol in diabetic patients. J Biochem. 1981 Jul;90(1):157–162. doi: 10.1093/oxfordjournals.jbchem.a133445. [DOI] [PubMed] [Google Scholar]
  2. Akanuma Y., Morita M., Fukuzawa N., Yamanouchi T., Akanuma H. Urinary excretion of 1,5-anhydro-D-glucitol accompanying glucose excretion in diabetic patients. Diabetologia. 1988 Nov;31(11):831–835. doi: 10.1007/BF00277486. [DOI] [PubMed] [Google Scholar]
  3. Dozois K. P., Carr C. J., Krantz J. C., Hachtel F., Beck F. F. Sugar Alcohols. VI: Utilization of Sugar Alcohols and Their Anhydrides by Various Microörganisms. J Bacteriol. 1936 Nov;32(5):499–503. doi: 10.1128/jb.32.5.499-503.1936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kametani S., Hashimoto Y., Yamanouchi T., Akanuma Y., Akanuma H. Reduced renal reabsorption of 1,5-anhydro-D-glucitol in diabetic rats and mice. J Biochem. 1987 Dec;102(6):1599–1607. doi: 10.1093/oxfordjournals.jbchem.a122210. [DOI] [PubMed] [Google Scholar]
  5. Morita M., Akanuma H. Distribution of 1,5-anhydro-D-glucitol in normal, diabetic, and perfused rat bodies. J Biochem. 1992 Sep;112(3):385–388. doi: 10.1093/oxfordjournals.jbchem.a123909. [DOI] [PubMed] [Google Scholar]
  6. Nakamura T., Naito A., Takahashi Y., Akanuma H. Oxidation of 1,5-anhydro-D-glucitol to 1,5-anhydro-D-fructose catalyzed by an enzyme from bacterial membranes. J Biochem. 1986 Mar;99(3):607–613. doi: 10.1093/oxfordjournals.jbchem.a135519. [DOI] [PubMed] [Google Scholar]
  7. Pitkänen E. Occurrence of I,5-anhydroglucitol in human cerebrospinal fluid. Clin Chim Acta. 1973 Oct 12;48(2):159–166. doi: 10.1016/0009-8981(73)90361-6. [DOI] [PubMed] [Google Scholar]
  8. Servo C., Pitkänen E. Variation in polyol levels in cerebrospinal fluid and serum in diabetic patients. Diabetologia. 1975 Dec;11(6):575–580. doi: 10.1007/BF01222109. [DOI] [PubMed] [Google Scholar]
  9. Smith S. L., Novotny M., Weber E. L. Gas-chromatographic determination of polyol profiles in cerebrospinal fluid. Clin Chem. 1978 Apr;24(4):545–548. [PubMed] [Google Scholar]
  10. Tetsuo M., Hamada T., Yoshimatsu K., Ishimatsu J., Matsunaga T. Serum levels of 1,5-anhydro-D-glucitol during the normal and diabetic pregnancy and puerperium. Acta Obstet Gynecol Scand. 1990;69(6):479–485. doi: 10.3109/00016349009013322. [DOI] [PubMed] [Google Scholar]
  11. Yamanouchi T., Akanuma H., Asano T., Konishi C., Akaoka I., Akanuma Y. Reduction and recovery of plasma 1,5-anhydro-D-glucitol level in diabetes mellitus. Diabetes. 1987 Jun;36(6):709–715. doi: 10.2337/diab.36.6.709. [DOI] [PubMed] [Google Scholar]
  12. Yamanouchi T., Akanuma H., Nakamura T., Akaoka I., Akanuma Y. Reduction of plasma 1,5-anhydroglucitol (1-deoxyglucose) concentration in diabetic patients. Diabetologia. 1988 Jan;31(1):41–45. doi: 10.1007/BF00279131. [DOI] [PubMed] [Google Scholar]
  13. Yamanouchi T., Akanuma H., Takaku F., Akanuma Y. Marked depletion of plasma 1,5-anhydroglucitol, a major polyol, in streptozocin-induced diabetes in rats and the effect of insulin treatment. Diabetes. 1986 Feb;35(2):204–209. doi: 10.2337/diab.35.2.204. [DOI] [PubMed] [Google Scholar]
  14. Yamanouchi T., Tachibana Y., Akanuma H., Minoda S., Shinohara T., Moromizato H., Miyashita H., Akaoka I. Origin and disposal of 1,5-anhydroglucitol, a major polyol in the human body. Am J Physiol. 1992 Aug;263(2 Pt 1):E268–E273. doi: 10.1152/ajpendo.1992.263.2.E268. [DOI] [PubMed] [Google Scholar]
  15. Yoshioka S., Saitoh S., Fujisawa T., Fujimori A., Takatani O., Funabashi M. Identification and metabolic implication of 1-deoxyglucose (1,5-anhydroglucitol) in human plasma. Clin Chem. 1982 Jun;28(6):1283–1286. [PubMed] [Google Scholar]
  16. Yoshioka S., Saitoh S., Negishi C., Fujisawa T., Fujimori A., Takatani O., Imura M., Funabashi M. Variations of 1-deoxyglucose(1,5-anhydroglucitol) content in plasma from patients with insulin-dependent diabetes mellitus. Clin Chem. 1983 Jul;29(7):1396–1398. [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES