Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1981 Aug;73(4):933–938. doi: 10.1111/j.1476-5381.1981.tb08748.x

Effects of cyclic AMP- and cyclic GMP- phosphodiesterase inhibitors on immunological release of histamine and on lung contraction.

N Frossard, Y Landry, G Pauli, M Ruckstuhl
PMCID: PMC2071496  PMID: 6168323

Abstract

1 Cyclic adenosine 3',5'-monophosphate (cyclic AMP)- and cyclic guanosine 3',5'-monophosphate (cyclic GMP)-phosphodiesterase activities from rat lung were selectively inhibited by ZK 62711 and M & B 22948, respectively. Theophylline and papaverine inhibited both activities. 2 Rat lung strips contracted by carbachol were relaxed by 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 26711, EC25 = 7 x 10(-8)M) and 2-O-propoxyphenyl-8-azapurin-6-one (M & B 22948, EC25 = 5 x 10(-7)M) indicating relaxant properties of both cyclic AMP and cyclic GMP. 3 The antigen-induced histamine release from human basophils was inhibited by ZK 62711 (IC25 = 8 x 10(-7)M), whereas M & B 22948 had no effect. On the contrary, the release from rat mast cells was inhibited by M & B 22948 (IC25 = 10(-6)M), while ZK 62711 had no effect. 4 These data show an inhibitory effect of cyclic AMP on histamine release to be involved with basophils, whereas cyclic GMP is predominantly involved with mast cells. Is is suggested that the antianaphylactic properties of cyclic nucleotide phosphodiesterase inhibitors are mainly linked to the increase of cyclic GMP.

Full text

PDF
934

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Assem E. S., Mongar J. L. Inhibition of allergic reactions in man and other species by cromoglycate. Int Arch Allergy Appl Immunol. 1970;38(1):68–77. doi: 10.1159/000230260. [DOI] [PubMed] [Google Scholar]
  2. Assem E. S., Schild H. O. Inhibition by sympathomimetic amines of histamine release by antigen in passively sensitized human lung. Nature. 1969 Dec 6;224(5223):1028–1029. doi: 10.1038/2241028a0. [DOI] [PubMed] [Google Scholar]
  3. BUTCHER R. W., SUTHERLAND E. W. Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. J Biol Chem. 1962 Apr;237:1244–1250. [PubMed] [Google Scholar]
  4. Bergstrand H., Kristoffersson J., Lundquist B., Schurmann A. Effects of antiallergic agents, compound 48/80, and some reference inhibitors on the activity of partially purified human lung tissue adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate phosphodiesterases. Mol Pharmacol. 1977 Jan;13(1):38–43. [PubMed] [Google Scholar]
  5. Broughton B. J., Chaplen P., Knowles P., Lunt E., Pain D. L., Wooldridge K. R., Ford R., Marshall S., Walker J. L., Maxwell D. R. New inhibitor of reagin-mediated anaphylaxis. Nature. 1974 Oct 18;251(5476):650–652. doi: 10.1038/251650a0. [DOI] [PubMed] [Google Scholar]
  6. Conolly M. E. Cyclic nucleotides, beta receptors, and bronchial asthma. Adv Cyclic Nucleotide Res. 1980;12:151–159. [PubMed] [Google Scholar]
  7. Coulson C. J., Ford R. E., Marshall S., Walker J. L., Wooldridge K. R., Bowden K., Coombs T. J. Interrelationship of cyclic nucleotides and anaphylactic reactions. Nature. 1977 Feb 10;265(5594):545–547. doi: 10.1038/265545a0. [DOI] [PubMed] [Google Scholar]
  8. Diamond J., Blisard K. S. Effects of stimulant and relaxant drugs on tension and cyclic nucleotide levels in canine femoral artery. Mol Pharmacol. 1976 Jul;12(4):668–692. [PubMed] [Google Scholar]
  9. Evans D. P., Thomson D. S. Inhibition of immediate hypersensitivity reactions in laboratory animals by a phenanthroline salt (ICI 74,917). Br J Pharmacol. 1975 Mar;53(3):409–418. doi: 10.1111/j.1476-5381.1975.tb07377.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fredholm B. B., Brodin K., Strandberg K. On the mechanism of relaxation of tracheal muscle by theophylline and other cyclic nucleotide phosphodiesterase inhibitors. Acta Pharmacol Toxicol (Copenh) 1979 Nov;45(5):336–344. doi: 10.1111/j.1600-0773.1979.tb02402.x. [DOI] [PubMed] [Google Scholar]
  11. Ishizaka T., Ishizaka K., Orange R. P., Austen K. F. Pharmacologic inhibition of the antigen-induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from monkey lung tissues mediated by human IgE. J Immunol. 1971 May;106(5):1267–1273. [PubMed] [Google Scholar]
  12. Jarrett E. E. Stimuli for the production and control of IgE in rats. Immunol Rev. 1978;41:52–76. doi: 10.1111/j.1600-065x.1978.tb01460.x. [DOI] [PubMed] [Google Scholar]
  13. Kaliner M. Human lung tissue and anaphylaxis. I. The role of cyclic GMP as a modulator of the immunologically induced secretory process. J Allergy Clin Immunol. 1977 Sep;60(3):204–211. doi: 10.1016/0091-6749(77)90125-7. [DOI] [PubMed] [Google Scholar]
  14. Kaliner M., Orange R. P., Austen K. F. Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. J Exp Med. 1972 Sep 1;136(3):556–567. doi: 10.1084/jem.136.3.556. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Keravis T. M., Wells J. N., Hardman J. G. Cyclic nucleotide phosphodiesterase activities from pig coronary arteries. Lack of interconvertibility of major forms. Biochim Biophys Acta. 1980;613(1):116–129. doi: 10.1016/0005-2744(80)90198-9. [DOI] [PubMed] [Google Scholar]
  16. Kukovetz W. R., Holzmann S., Wurm A., Pöch G. Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 1979 Dec;310(2):129–138. doi: 10.1007/BF00500277. [DOI] [PubMed] [Google Scholar]
  17. LICHTENSTEIN L. M., OSLER A. G. STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENA. IX. HISTAMINE RELEASE FROM HUMAN LEUKOCYTES BY RAGWEED POLLEN ANTIGEN. J Exp Med. 1964 Oct 1;120:507–530. doi: 10.1084/jem.120.4.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lichtenstein L. M., Margolis S. Histamine release in vitro: inhibition by catecholamines and methylxanthines. Science. 1968 Aug 30;161(3844):902–903. doi: 10.1126/science.161.3844.902. [DOI] [PubMed] [Google Scholar]
  19. Lichtenstein L. M., Sobotka A. K., Malveaux F. J., Gillespie E. IgE-induced changes in human basophil cyclic AMP levels. Int Arch Allergy Appl Immunol. 1978;56(5):473–478. doi: 10.1159/000232059. [DOI] [PubMed] [Google Scholar]
  20. Lulich K. M., Mitchell H. W., Sparrow M. P. The cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. Br J Pharmacol. 1976 Sep;58(1):71–79. doi: 10.1111/j.1476-5381.1976.tb07694.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Murad F., Kimura H. Cyclic nucleotide levels in incubations of guinea pig trachea. Biochim Biophys Acta. 1974 Apr 22;343(2):275–286. doi: 10.1016/0304-4165(74)90092-0. [DOI] [PubMed] [Google Scholar]
  22. Orange R. P., Kaliner M. A., Laraia P. J., Austen K. F. Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. II. Influence of cellular levels of cyclic AMP. Fed Proc. 1971 Nov-Dec;30(6):1725–1729. [PubMed] [Google Scholar]
  23. Ruckstuhl M., Beretz A., Anton R., Landry Y. Flavonoids are selective cyclic GMP phosphodiesterase inhibitors. Biochem Pharmacol. 1979;28(4):535–538. doi: 10.1016/0006-2952(79)90249-1. [DOI] [PubMed] [Google Scholar]
  24. Ruckstuhl M., Landry Y. Inhibition of lung cyclic AMP- and cyclic GMP-phosphodiesterases by flavonoids and other chromone-like compounds. Biochem Pharmacol. 1981 Apr 1;30(7):697–702. doi: 10.1016/0006-2952(81)90153-2. [DOI] [PubMed] [Google Scholar]
  25. SHORE P. A., BURKHALTER A., COHN V. H., Jr A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther. 1959 Nov;127:182–186. [PubMed] [Google Scholar]
  26. Schultz K., Schultz K., Schultz G. Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens. Nature. 1977 Feb 24;265(5596):750–751. doi: 10.1038/265750a0. [DOI] [PubMed] [Google Scholar]
  27. Schwabe U., Miyake M., Ohga Y., Daly J. W. 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a potent inhibitor of adenosine cyclic 3',5'-monophosphate phosphodiesterases in homogenates and tissue slices from rat brain. Mol Pharmacol. 1976 Nov;12(6):900–910. [PubMed] [Google Scholar]
  28. Sullivan T. J., Parker K. L., Kulczycki A., Jr, Parker C. W. Modulation of cyclic AMP in purified rat mast cells. III. Studies on the effects of concanavalin A and anti-IgE on cyclic AMP concentrations during histamine release. J Immunol. 1976 Sep;117(3):713–716. [PubMed] [Google Scholar]
  29. VAN ROSSUM J. M. Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch Int Pharmacodyn Ther. 1963;143:299–330. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES