Abstract
1 Substance P and its natural analogues were tested for their effect on gastric emptying in the rat. 2 Substance P and kassinin were virtually inactive even at the maximum dose tests. 3 The other tachykinins significantly delayed gastric emptying their effect being quite remarkable with 100 micrograms/kg. The lowest doses (30 microgram/kg) caused a slight and non-significant increase in emptying rate. 4 The effect on gastric emptying was most probably correlated with a spasmogenic effect on the gastroduodenal junction, as pointed out in previous work.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bertaccini G. Active polypeptides of nonmammalian origin. Pharmacol Rev. 1976 Jun;28(2):127–177. [PubMed] [Google Scholar]
- Bertaccini G., Coruzzi G. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163–166. doi: 10.1007/BF00508624. [DOI] [PubMed] [Google Scholar]
- Bertaccini G., Impicciatore M. Action of bombesin on the motility of the stomach. Naunyn Schmiedebergs Arch Pharmacol. 1975;289(2):149–156. [PubMed] [Google Scholar]
- Bertaccini G., Impicciatore M., De Caro G. Action of caerulein and related substances on the pyloric sphincter of the anaesthetized rat. Eur J Pharmacol. 1973 Jun;22(3):320–324. doi: 10.1016/0014-2999(73)90032-0. [DOI] [PubMed] [Google Scholar]
- Gerold M., Tschirky H. Measurement of blood pressure in unanaesthetized rats and mice. Arzneimittelforschung. 1968 Oct;18(10):1285–1287. [PubMed] [Google Scholar]
- Scarpignato C., Bertaccini G. Bombesin delays gastric emptying in the rat. Digestion. 1981;21(2):104–106. doi: 10.1159/000198549. [DOI] [PubMed] [Google Scholar]
- Scarpignato C., Capovilla T., Bertaccini G. Action of caerulein on gastric emptying of the conscious rat. Arch Int Pharmacodyn Ther. 1980 Aug;246(2):286–294. [PubMed] [Google Scholar]
- Széli J., Molina E., Zappia L., Bertaccini G. Action of some natural polypeptides on the longitudinal muscle of the guinea pig ileum. Eur J Pharmacol. 1977 Jun 1;43(3):285–287. doi: 10.1016/0014-2999(77)90030-9. [DOI] [PubMed] [Google Scholar]
- Yajima H., Sasaki T., Ogawa H., Juji N., Segawa T., Nakata Y. Studies on peptides. LXXVI. Synthesis of kassinin, a new frog skin peptide. Chem Pharm Bull (Tokyo) 1978 Apr;26(4):1231–1235. doi: 10.1248/cpb.26.1231. [DOI] [PubMed] [Google Scholar]
- Zappia L., Molina E., Sianesi M., Bertaccini G. Effects of natural analogues of substance P on the motility of human gastrointestinal tract in vitro. J Pharm Pharmacol. 1978 Sep;30(9):593–594. doi: 10.1111/j.2042-7158.1978.tb13335.x. [DOI] [PubMed] [Google Scholar]