Abstract
Acute coronary artery occlusion in anaesthetized open-chest greyhounds led to early release of thromboxane B2 (TxB2) into venous blood draining the ischaemic region. No release occurred from the remainder of the left ventricular wall (coronary sinus sampling). TxB2 release and ventricular ectopic activity were positively correlated (r = 0.863) 2 min post-occlusion. Aspirin (3 mg/kg i.v.) suppressed both local TxB2 release and ectopic activity and prevented ventricular fibrillation. It is suggested that TxB2 release is a factor contributing to early post-infarction arrhythmias.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Folts J. D., Crowell E. B., Jr, Rowe G. G. Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation. 1976 Sep;54(3):365–370. doi: 10.1161/01.cir.54.3.365. [DOI] [PubMed] [Google Scholar]
- Marshall R. J., Parratt J. R. Prophylactic lignocaine and early post-coronary artery occlusion dysrhythmias in anaesthetized greyhounds. Br J Pharmacol. 1980;71(2):597–600. doi: 10.1111/j.1476-5381.1980.tb10978.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moschos C. B., Haider B., De La Cruz C., Jr, Lyons M. M., Regan T. J. Antiarrhythmic effects of aspirin during nonthrombotic coronary occlusion. Circulation. 1978 Apr;57(4):681–684. doi: 10.1161/01.cir.57.4.681. [DOI] [PubMed] [Google Scholar]