Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1981 Sep;74(1):7–9. doi: 10.1111/j.1476-5381.1981.tb09947.x

Histamine release from human right atrium.

R W Gristwood, J C Lincoln, D A Owen, I R Smith
PMCID: PMC2071876  PMID: 6168324

Abstract

Histamine release has been detected biologically after exposure of human right atrial biopsy samples to compound 48/80. Human right atrial samples contain large quantities of histamine, 1035 +/- 65 ng/g fresh weight. Exposure of untreated electrically paced atrial strips to compound 84/80, 300 micro/ml, caused an increase in the force of atrial contraction similar to that caused by histamine. Pretreatment of strips with cimetidine, 3.16 x 10(-5) M, prevented the inotropic response to compound 48/80. It is concluded that mast cell degranulation in human atrial tissue can cause sufficient release of histamine to modify the function of the heart.

Full text

PDF
7

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Capurro N., Levi R. Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine. Br J Pharmacol. 1973 Aug;48(4):620–628. doi: 10.1111/j.1476-5381.1973.tb08249.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Flynn S. B., Gristwood R. W., Owen D. A. Differentiation of the roles of histamine H1- and H2-receptors in the mediation of the effects of histamine in the isolated working heart of the guinea-pig. Br J Pharmacol. 1979 Jan;65(1):127–137. doi: 10.1111/j.1476-5381.1979.tb17341.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Giotti A., Guidotti A., Mannaioni P. F., Zilletti L. The influences of andrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro. J Physiol. 1966 Jun;184(4):924–941. doi: 10.1113/jphysiol.1966.sp007957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gristwood R. W., Lincoln J. C., Owen D. A. Effects of histamine on human isolated heart muscle: comparison with effects of noradrenaline. J Pharm Pharmacol. 1980 Feb;32(2):145–146. doi: 10.1111/j.2042-7158.1980.tb12875.x. [DOI] [PubMed] [Google Scholar]
  5. Knight R. I., Smith I. R., Brimblecombe R. W. Separation and quantification of metabolites of radiolabelled histamine in brain [proceedings]. Br J Pharmacol. 1978 Nov;64(3):460P–460P. [PMC free article] [PubMed] [Google Scholar]
  6. Levi R., Allan G., Zavecz J. H. Cardiac histamine receptors. Fed Proc. 1976 Jun;35(8):1942–1947. [PubMed] [Google Scholar]
  7. Levi R. Effects of exogenous and immunologically released histamine on the isolated heart: a quantitative comparison. J Pharmacol Exp Ther. 1972 Aug;182(2):227–238. [PubMed] [Google Scholar]
  8. Owen D. A. Histamine receptors in the cardiovascular. Gen Pharmacol. 1977;8(3):141–156. doi: 10.1016/0306-3623(77)90043-x. [DOI] [PubMed] [Google Scholar]
  9. Petch M. C., Nayler W. G. Concentration of catecholamines in human cardiac muscle. Br Heart J. 1979 Mar;41(3):340–344. doi: 10.1136/hrt.41.3.340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pöch G., Kukovetz W. R. Drug-induced release and pharmacodynamic effects of histamine in the guinea-pig heart. J Pharmacol Exp Ther. 1967 Jun;156(3):522–527. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES