Abstract
When Proteus mirabilis, Klebsiella aerogenes, Escherichia coli, a virulent (P14) and an avirulent (P2AB) strain of Pseudomonas aeruginosa were inoculated on to the burned surfaces of mice, only P. mirabilis and Ps. aeruginosa (P14) invaded the burns and caused septicaemia and death.
When burned mice were inoculated i.p. with the same Gram-negative bacilli, K. aerogenes was found to be as pathogenic as Pr. mirabilis; Ps. aeruginosa (P14) was the most lethal organism and Esch. coli and Ps. aeruginosa (P2AB) only caused death when 7 × 109 organisms were inoculated.
Antisera, against the infecting strains, given to burned mice before infection prevented septicaemia and death in mice infected i.p. with Ps. aeruginosa (P14) and Pr. mirabilis but was less effective in protecting burned mice infected i.p. with Esch. coli and K. aerogenes.
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Selected References
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