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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1971 Feb;52(1):100–109.

Early Protection by Vaccines in burns

R J Jones
PMCID: PMC2072283  PMID: 4993954

Abstract

Groups of mice, inoculated once a week for 3 weeks with vaccines from culture filtrates of Pseudomonas aeruginosa and Proteus mirabilis and slime from Klebsiella aerogenes, were protected against lethal infections with the homologous strains injected intraperitoneally after burning.

A single injection of pseudomonas and proteus vaccines also protected burned and unburned mice against lethal, homologous, i.p. infections as early as 24-48 hr after vaccination. The klebsiella vaccine did not induce early protection. A single injection of a trivalent vaccine, made by combining pseudomonas, proteus and klebsiella vaccines in equal proportions, protected burned mice against lethal K. aerogenes, Ps. aeruginosa and Pr. mirabilis infections.

Mice which were protected against homologous infections had no detectable agglutinins in their sera until three days after the protective response had been demonstrated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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