Abstract
Protein deficiency at the time of dosage protects rats against the acute lethal effects of dimethyl nitrosamine, but increases the late carcinogenic actions of the poison.
A single dose of 60 mg. dimethyl nitrosamine/kg. leads to the development of kidney cancers in all the surviving rats after 8-11 months. 40 mg./kg. produces tumours in over half of the survivors in 14 months.
Induction of liver microsomal hydroxylation enzymes with phenobarbitone does not prevent the carcinogenic effects of dimethyl nitrosamine.
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Selected References
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