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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1971 Dec;52(6):669–677.

Infection Patterns in Mice of an Avirulent and Virulent Strain of Semliki Forest Virus

Rozalia Pusztai, E A Gould, H Smith
PMCID: PMC2072387  PMID: 5135538

Abstract

Young mice injected i.p. with a virulent (V 13) or an avirulent (A 7) strain of Semliki Forest virus suffered a severe generalized infection over the first 2 days with prolific virus replication in the peritoneal wall and other muscle. This replication and the level of the resulting viraemia were as high for A 7 as V 13 and possibly higher. Despite this similarity in the extent of systemic infection significant replication of V 13 was detectable in the brain, the probable site of fatal damage, at 36-40 hr, 12 hr before that of A 7: and subsequently V 13 increased until death of the mice whereas A 7 declined. After intracerebral inoculation early virus replication in the brain was similar for both strains and a generalized infection ensued similar in extent to that seen after intraperitoneal injection. Within 24 hr a primary injection of the avirulent strain by either route protected mice against a subsequent injection of the virulent strain. The different patterns of brain infection occurring after intraperitoneal injection are probably due to differential interactions of the 2 virus strains with host defence mechanisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BANG F. B., LUTTRELL C. N. Factors in the pathogenesis of virus diseases. Adv Virus Res. 1961;8:199–244. doi: 10.1016/s0065-3527(08)60686-7. [DOI] [PubMed] [Google Scholar]
  2. Bradish C. J., Allner K., Maber H. B. The virulence of original and derived strains of Semliki forest virus for mice, guinea-pigs and rabbits. J Gen Virol. 1971 Aug;12(2):141–160. doi: 10.1099/0022-1317-12-2-141. [DOI] [PubMed] [Google Scholar]
  3. Campbell J. B., Buera J. G., Tobias F. M. Influence of blood clearance rates on interferon production and virulence of Mengo virus plaque mutants in mice. Can J Microbiol. 1970 Sep;16(9):821–826. doi: 10.1139/m70-138. [DOI] [PubMed] [Google Scholar]
  4. Murphy F. A., Harrison A. K., Collin W. K. The role of extraneural arbovirus infection in the pathogenesis of encephalitis. An electron microscopic study of Semliki Forest virus infection in mice. Lab Invest. 1970 Apr;22(4):318–328. [PubMed] [Google Scholar]
  5. Seamer J., Randles W. J., Fitzgeorge R. The course of Semliki Forest virus infection in mice. Br J Exp Pathol. 1967 Aug;48(4):395–402. [PMC free article] [PubMed] [Google Scholar]

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