Abstract
Segmental circumscribed pyelonephritis in rabbits was associated with a significant increase in the incorporation of 14C amino acids into IgG by the infected kidneys and spleen. Specific anti-Esch. coli antibody in the IgG class was synthesized by 8 of 10 kidneys, 5 of 10 spleens, 1 of 6 proximal lymph nodes, 1 of 3 popliteal lymph nodes and by none of the “buffy coat” cells (circulating lymphocytes). Although viable organisms were not present, non-viable antigen persisted for up to 6 months after infection. Persistent circulating antibody may arise from local antibody which is stimulated by the persistence of non-viable antigen at site of infection.
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Selected References
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