Skip to main content
PMC home page
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1973 Feb;54(1):56–68.

Activity of the Reticuloendothelial System and the Antibody Response

I. Effect of Stilboestrol on RES Activity and Localization of Sheep Erythrocytes in the Mouse

G W Warr, V S Šljivič
PMCID: PMC2072506  PMID: 4120350

Abstract

The stimulatory effect of stilboestrol on the RES of the mouse was assessed in terms of the blood clearance and organ uptake of colloidal carbon, sheep RBC and heat damaged mouse RBC, and comparison made between the effect on the RES of stilboestrol and endotoxin. Pretreatment with stilboestrol caused an increase of hepatic uptake of test materials and a reduction of carbon and SRBC localization in the spleen. Incorporation of [3H]thymidine and the proportion of labelled cells were increased in livers and spleens of stilboestrol treated animals.

Full text

PDF
63

Images in this article

58-1Fig. 1
on p.58-1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CUTLER J. L. The effect of Zymosan on the phagocytosis of foreign erythrocytes. J Immunol. 1961 Jan;86:73–78. [PubMed] [Google Scholar]
  2. Di Luzio N. R., Morrow H. S., 3rd Comparative behavior of soluble and particulate antigens and inert colloids in reticuloendothelial-stimulated or depressed mice. J Reticuloendothel Soc. 1971 Mar;9(3):273–287. [PubMed] [Google Scholar]
  3. HELLER J. H., MEIER R. M., ZUCKER R., MAST G. W. The effect of natural and synthetic estrogens on reticuloendothelial system function. Endocrinology. 1957 Sep;61(3):235–241. doi: 10.1210/endo-61-3-235. [DOI] [PubMed] [Google Scholar]
  4. Harris G., Pelc S. R. Incorporation of [3H] thymidine into the spleens of intact mice during the immune response to sheep erythrocytes (SRC). Immunology. 1970 Dec;19(6):865–878. [PMC free article] [PubMed] [Google Scholar]
  5. KELLY L. S., BROWN B. A., DOBSON E. L. Cell division and phagocytic activity in liver reticulo-endothelial cells. Proc Soc Exp Biol Med. 1962 Jul;110:555–559. doi: 10.3181/00379727-110-27578. [DOI] [PubMed] [Google Scholar]
  6. KELLY L. S., DOBSON E. L., FINNEY C. R., HIRSCH J. D. Proliferation of the reticuloendothelial system in the liver. Am J Physiol. 1960 May;198:1134–1138. doi: 10.1152/ajplegacy.1960.198.5.1134. [DOI] [PubMed] [Google Scholar]
  7. Kelly L. S., Dobson E. L. Evidence concerning the origin of liver macrophages. Br J Exp Pathol. 1971 Feb;52(1):88–99. [PMC free article] [PubMed] [Google Scholar]
  8. Kinsky R. G., Christie G. H., Elson J., Howard J. G. Extra-hepatic derivation of Kupffer cells during oestrogenic stimulation of parabiosed mice. Br J Exp Pathol. 1969 Oct;50(5):438–447. [PMC free article] [PubMed] [Google Scholar]
  9. NICOL T., BILBEY D. L., CHARLES L. M., CORDINGLEY J. L., VERNON-ROBERTS B. OESTROGEN: THE NATURAL STIMULANT OF BODY DEFENCE. J Endocrinol. 1964 Oct;30:277–291. doi: 10.1677/joe.0.0300277. [DOI] [PubMed] [Google Scholar]
  10. Perrin J. The effect of cortisone and oestradiol on the sequestration of red cells in mice. J Pathol Bacteriol. 1965 Jul;90(1):311–318. doi: 10.1002/path.1700900135. [DOI] [PubMed] [Google Scholar]
  11. Sljivić V. S. A quantitative method for measuring the uptake of colloidal carbon by mouse tissues. Experientia. 1969 Sep 15;25(9):1004–1006. doi: 10.1007/BF01898120. [DOI] [PubMed] [Google Scholar]
  12. Sljivić V. S. Radiation and the phagocytic function of the reticuloendothelial system. I. Enhancement of RES function in x-irradiated mice. Br J Exp Pathol. 1970 Apr;51(2):130–139. [PMC free article] [PubMed] [Google Scholar]
  13. Sljivić V. S., Warr G. W. Activity of the reticuloendothelial system and the antibody response. II. Effect of stilboestrol on the immune response to sheep erythrocytes in the mouse. Br J Exp Pathol. 1973 Feb;54(1):69–78. [PMC free article] [PubMed] [Google Scholar]
  14. Souhami R. L. The effect of colloidal carbon on the organ distribution of sheep red cells and the immune response. Immunology. 1972 Apr;22(4):685–694. [PMC free article] [PubMed] [Google Scholar]
  15. Thompson J. S., Simmons E. L., Crawford M. K., Severson C. D. Studies on the mechanisms of estradiol-induced radioprotection. Radiat Res. 1969 Oct;40(1):70–84. [PubMed] [Google Scholar]
  16. Vernon-Roberts B. The effects of steroid hormones on macrophage activity. Int Rev Cytol. 1969;25:131–159. doi: 10.1016/s0074-7696(08)60202-8. [DOI] [PubMed] [Google Scholar]
  17. Warr G. W., Sljivíc V. Stilboestrol-induced depression of the antibody response. Experientia. 1972 Nov 15;28(11):1356–1359. doi: 10.1007/BF01965343. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Experimental Pathology are provided here courtesy of Wiley

RESOURCES