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. 1974 Apr;55(2):194–202.

The Stimulation by Endotoxin of the Nonspecific Resistance of Mice to Bacterial Infections

A W Hill, K G Hibbitt, A Shears
PMCID: PMC2072531  PMID: 4599349

Abstract

The nonspecific resistance of mice to challenge was enhanced following the administration of an E. coli O55 B5 endotoxin. Although the route of administration of the endotoxin and the challenge organism were varied, the nonspecific resistance of the animal was enhanced in all the experiments. The efficiency of this resistance was highest when the inducing substance and the challenge dose of bacteria were administered intraperitoneally. Poly I: C and double stranded RNA were also studied but were much less effective than endotoxin in stimulating a resistance to infection.

Stimulation of the fixed macrophages could not explain fully the enhanced resistance, since the clearance rates of colloidal carbon and radioactively labelled bacteria from the blood were not significantly enhanced after the administration of endotoxin. Furthermore, splenectomized animals, and animals injected with agents which interfere with the RES activity, trypan blue and corticosteroids, still developed a degree of nonspecific resistance to infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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