Abstract
Retronecine pyrrole induces toxic changes both in human liver and lung cells. Lasiocarpine and retrorsine are toxic to liver cells but not to lung cells, which are unable to metabolize the pyrrolizidine alkaloids to pyrroles. The application of lasiocarpine to human liver cells in culture is followed by inhibition of DNA, RNA and protein synthesis; vacuolation of the cells, the prevention of mitosis and the formation of giant cells (“megalocytes”).
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Selected References
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- Armstrong S. J., Zuckerman A. J. Production of pyrroles from pyrrolizidine alkaloids by human embryo tissue. Nature. 1970 Nov 7;228(5271):569–570. doi: 10.1038/228569a0. [DOI] [PubMed] [Google Scholar]
- BARNES J. M., MAGEE P. N., SCHOENTAL R. LESIONS IN THE LUNGS AND LIVERS OF RATS POISONED WITH THE PYRROLIZIDINE ALKALOID FULVINE AND ITS N-OXIDE. J Pathol Bacteriol. 1964 Oct;88:521–531. doi: 10.1002/path.1700880215. [DOI] [PubMed] [Google Scholar]
- Black D. N., Jago M. V. Interaction of dehydroheliotridine, a metabolite of heliotridine-based pyrrolizidine alkaloids, with native and heat-denatured deoxyribonucleic acid in vitro. Biochem J. 1970 Jul;118(3):347–353. doi: 10.1042/bj1180347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harris C., Reddy J., Chiga M., Svoboda D. Polyribosome disaggregation in rat liver by lasiocarpine. Biochim Biophys Acta. 1969 Jun 17;182(2):587–589. doi: 10.1016/0005-2787(69)90218-4. [DOI] [PubMed] [Google Scholar]
- Mattocks A. R. Toxicity of pyrrolizidine alkaloids. Nature. 1968 Feb 24;217(5130):723–728. doi: 10.1038/217723a0. [DOI] [PubMed] [Google Scholar]
- SELZER G., PARKER R. G. F., SAPEIKA N. An experimental study of senecio poisoning in rats. Br J Exp Pathol. 1951 Feb;32(1):14–20. [PMC free article] [PubMed] [Google Scholar]
- Zuckerman A. J., Rees K. R., Inman D. R., Robb I. A. The effects of aflatoxins on human embryo liver cells in culture. Br J Exp Pathol. 1968 Feb;49(1):33–39. [PMC free article] [PubMed] [Google Scholar]
- Zuckerman A. J., Tsiquaye K. N., Fulton F. Tissue culture of human embryo liver cells and the cytotoxicity of aflatoxin B1. Br J Exp Pathol. 1967 Feb;48(1):20–27. [PMC free article] [PubMed] [Google Scholar]