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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1973 Apr;54(2):198–202.

The Effect of Malaria on the Relative Affinity of Mouse Antiprotein Antibody

M W Steward, A Voller
PMCID: PMC2072574  PMID: 4573426

Abstract

Inbred mice infected with Plasmodium berghei yoellii produce antibody of significantly lower relative affinity to human serum transferrin than do uninfected animals of the same strain. The levels of antibody produced were similar in both groups. The possibility that the infection resulted in partial immunosuppression is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alpers J. H., Steward M. W., Soothill J. F. Differences in immune elimination in inbred mice. The role of low affinity antibody. Clin Exp Immunol. 1972 Sep;12(1):121–132. [PMC free article] [PubMed] [Google Scholar]
  2. Greenwood B. M., Brown J. C., De Jesus D. G., Holborow E. J. Immunosuppression in murine malaria. II. The effect on reticulo-endothelial and germinal centre function. Clin Exp Immunol. 1971 Sep;9(3):345–354. [PMC free article] [PubMed] [Google Scholar]
  3. Greenwood B. M., Playfair J. H., Torrigiani G. Immunosuppression in murine malaria. I. General characteristics. Clin Exp Immunol. 1971 Mar;8(3):467–478. [PMC free article] [PubMed] [Google Scholar]
  4. Greenwood B. M., Voller A. Suppression of autoimmune disease in New Zealand mice associated with infection with malaria. I. (NZBxNZW) F1 hybrid mice. Clin Exp Immunol. 1970 Dec;7(6):793–803. [PMC free article] [PubMed] [Google Scholar]
  5. Greenwood B. M., Voller A. Suppression of autoimmune disease in New Zealand mice associated with infection with malaria. II. NZB mice. Clin Exp Immunol. 1970 Dec;7(6):805–815. [PMC free article] [PubMed] [Google Scholar]
  6. Petty R. E., Steward M. W. Relative affinity of anti-protein antibodies in New Zealand mice. Clin Exp Immunol. 1972 Nov;12(3):343–350. [PMC free article] [PubMed] [Google Scholar]
  7. Petty R. E., Steward M. W., Soothill J. F. The heterogeneity of antibody affinity in inbred mice and its possible immunopathologic significance. Clin Exp Immunol. 1972 Oct;12(2):231–241. [PMC free article] [PubMed] [Google Scholar]
  8. Salaman M. H., Wedderburn N., Bruce-Chwatt L. J. The immunodepressive effect of a murine plasmodium and its interaction with murine oncogenic viruses. J Gen Microbiol. 1969 Dec;59(3):383–391. doi: 10.1099/00221287-59-3-383. [DOI] [PubMed] [Google Scholar]
  9. Steward M. W., Petty R. E. The antigen-binding characteristics of antibody pools of different relative affinity. Immunology. 1972 Dec;23(6):881–887. [PMC free article] [PubMed] [Google Scholar]
  10. Steward M. W., Petty R. E. The use of ammonium sulphate globulin precipitation for determination of affinity of anti-protein antibodies in mouse serum. Immunology. 1972 May;22(5):747–756. [PMC free article] [PubMed] [Google Scholar]
  11. Voller A., Gall D., Manawadu B. R. Depression of the antibody response to tetanus toxoid in mice infected with malaria parasites. Z Tropenmed Parasitol. 1972 Jun;23(2):152–155. [PubMed] [Google Scholar]

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