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. 1973 Apr;54(2):142–151.

Experimental Bacterial Endocarditis

III. Production and Progress of the Disease in Rabbits

D T Durack, P B Beeson, R G Petersdorf
PMCID: PMC2072580  PMID: 4700697

Abstract

A simple and reliable model for endocarditis in rabbits has been studied and standardized. Non-bacterial thrombotic endocarditis was produced on either side of the heart by the presence of a polyethylene catheter. One day later, this was converted into bacterial endocarditis by single intravenous injections of streptococci, staphylococci, Proteus and Candida. No infection resulted from injection of L-forms or virus. Reduction of inoculum size or withdrawal of the catheter reduced the incidence of bacterial endocarditis, but the presence of a catheter in the heart for only a few minutes predisposed to infection. Left-sided Streptococcus viridans infection was uniformly fatal, with average survival of about two weeks. Right-sided infection was not always fatal; approximately 25% of infected vegetations healed spontaneously.

The advantages of a standardized model for endocarditis which allows exact timing of infection are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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