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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1973 Jun;54(3):283–290.

Treatment of “Bacterial Cystitis” in Fully Automatic Mechanical Models Simulating Conditions of Bacterial Growth in the Urinary Bladder

F O'Grady, I P Mackintosh, D Greenwood, B W Watson
PMCID: PMC2072600  PMID: 4577943

Abstract

Two fully automatic models are described in which growing cultures can be continuously diluted and periodically discharged producing conditions of growth resembling those of the infected urinary bladder. Both models generate a continuous record of the opacity of the growing culture and the second model also generates a record of the Eh. The effect of adding ampicillin to a sensitive strain of Escherichia coli growing in these conditions is described and the relation of the results to human therapy is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Greenwood D., O'Grady F. A comparison of the effects of ampicillin on Escherichia coli and proteus mirabilis. J Med Microbiol. 1969 Nov 4;2(4):435–441. doi: 10.1099/00222615-2-4-435. [DOI] [PubMed] [Google Scholar]
  2. Greenwood D., O'Grady F. The effect of osmolality on the response of Escherichia coli and Proteus mirabilis to penicillins. Br J Exp Pathol. 1972 Oct;53(5):457–464. [PMC free article] [PubMed] [Google Scholar]
  3. Greenwood D., O'Grady F. Trimodal response of Escherichia coli and Proteus mirabilis to penicillins. Nature. 1970 Oct 31;228(5270):457–458. doi: 10.1038/228457a0. [DOI] [PubMed] [Google Scholar]
  4. O'Grady F., Cattell W. R. Kinetics of urinary tract infection. II. The bladder. Br J Urol. 1966 Apr;38(2):156–162. doi: 10.1111/j.1464-410x.1966.tb09694.x. [DOI] [PubMed] [Google Scholar]
  5. O'Grady F., Pennington J. H. Bacterial growth in an in vitro system simulating conditions in the urinary bladder. Br J Exp Pathol. 1966 Apr;47(2):152–157. [PMC free article] [PubMed] [Google Scholar]
  6. O'Grady F., Pennington J. H. Synchronized micturition and antibiotic administration in treatment of urinary infection in an in vitro model. Br Med J. 1967 Feb 18;1(5537):403–406. doi: 10.1136/bmj.1.5537.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ormonde N. W., Gray J. A., Murdoch J. M., Wallace E., Brumfitt W., Pursell R., Regan J. W. Chronic bacteriuria due to Escherichia coli. I. Assessment of the value of combined short- and long-term treatment with cycloserine, nitrofurantoin, and sulphadimidine. J Infect Dis. 1969 Jul;120(1):82–86. doi: 10.1093/infdis/120.1.82. [DOI] [PubMed] [Google Scholar]
  8. Watson B. W., Gauci C. L., Blache L., O'Grady F. W. A simple turbidity cell for continuously monitoring the growth of bacteria. Phys Med Biol. 1969 Oct;14(4):555–558. doi: 10.1088/0031-9155/14/4/302. [DOI] [PubMed] [Google Scholar]

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