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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1974 Aug;55(4):344–351.

An Investigation into the Immunogenicity of Various Components of Osteoarticular Grafts

M W Elves, J Zervas
PMCID: PMC2072653  PMID: 4433468

Abstract

Rats have been grafted subcutaneously with heterografts of sheep osteoarticular tissues. Antibody against sheep transplantation antigens has been sought. The results of the studies indicate that articular cartilage alone is poorly immunogenic and if it does lead to an immune response, this response is delayed; it is the bone components of the composite osteoarticular grafts which are highly immunogenic and in most recipients cause a brisk production of antibodies.

It is suggested that the cartilage matrix forms a protective barrier to both the afferent and the efferent arms of the immune response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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