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. 1996 Mar;73(5):698–701. doi: 10.1038/bjc.1996.121

A case-control study of cryptorchidism and maternal hormone concentrations in early pregnancy.

T J Key 1, D Bull 1, P Ansell 1, A R Brett 1, G M Clark 1, J W Moore 1, C E Chilvers 1, M C Pike 1
PMCID: PMC2074338  PMID: 8605110

Abstract

Serum samples taken between 6 and 20 weeks of gestation were obtained from 28 mothers who gave birth to cryptorchid sons (cases) and from 108 control mothers. In comparison with controls the cases had 10% higher geometric mean oestradiol (95% CI -13% to +39%: P=0.42) and 10% lower geometric mean testosterone (95% CI -27% to +10%: P=0.30). Among the samples collected between 6 and 14 weeks of gestation geometric mean concentrations of oestradiol and testosterone were 5% lower (95% CI -32% to +31%: P=0.74) and 25% lower (95% CI -45% to +1%: P=0.06) respectively in cases than in controls. Among the samples collected between 15 and 20 weeks of gestation geometric mean concentrations of oestradiol and testosterone were 29% higher (95% CI -8% to +79%: P=0.14) and 21% higher (95% CI -8% to +60%: P=0.18) respectively in cases than in controls. The results do not support the hypothesis that cryptorchidism may be caused by high concentrations of oestradiol in the maternal blood during the first phase of testicular descent, but suggest that the possible association of cryptorchidism with low maternal testosterone during early gestation should be further investigated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernstein L., Depue R. H., Ross R. K., Judd H. L., Pike M. C., Henderson B. E. Higher maternal levels of free estradiol in first compared to second pregnancy: early gestational differences. J Natl Cancer Inst. 1986 Jun;76(6):1035–1039. [PubMed] [Google Scholar]
  2. Bernstein L., Pike M. C., Depue R. H., Ross R. K., Moore J. W., Henderson B. E. Maternal hormone levels in early gestation of cryptorchid males: a case-control study. Br J Cancer. 1988 Sep;58(3):379–381. doi: 10.1038/bjc.1988.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bernstein L., Pike M. C., Lobo R. A., Depue R. H., Ross R. K., Henderson B. E. Cigarette smoking in pregnancy results in marked decrease in maternal hCG and oestradiol levels. Br J Obstet Gynaecol. 1989 Jan;96(1):92–96. doi: 10.1111/j.1471-0528.1989.tb01582.x. [DOI] [PubMed] [Google Scholar]
  4. Burton M. H., Davies T. W., Raggatt P. R. Undescended testis and hormone levels in early pregnancy. J Epidemiol Community Health. 1987 Jun;41(2):127–129. doi: 10.1136/jech.41.2.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chilvers C., Dudley N. E., Gough M. H., Jackson M. B., Pike M. C. Undescended testis: the effect of treatment on subsequent risk of subfertility and malignancy. J Pediatr Surg. 1986 Aug;21(8):691–696. doi: 10.1016/s0022-3468(86)80389-x. [DOI] [PubMed] [Google Scholar]
  6. Depue R. H. Maternal and gestational factors affecting the risk of cryptorchidism and inguinal hernia. Int J Epidemiol. 1984 Sep;13(3):311–318. doi: 10.1093/ije/13.3.311. [DOI] [PubMed] [Google Scholar]
  7. Henderson B. E., Benton B., Jing J., Yu M. C., Pike M. C. Risk factors for cancer of the testis in young men. Int J Cancer. 1979 May 15;23(5):598–602. doi: 10.1002/ijc.2910230503. [DOI] [PubMed] [Google Scholar]
  8. Henderson B. E., Bernstein L., Ross R. K., Depue R. H., Judd H. L. The early in utero oestrogen and testosterone environment of blacks and whites: potential effects on male offspring. Br J Cancer. 1988 Feb;57(2):216–218. doi: 10.1038/bjc.1988.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hutson J. M. A biphasic model for the hormonal control of testicular descent. Lancet. 1985 Aug 24;2(8452):419–421. doi: 10.1016/s0140-6736(85)92739-4. [DOI] [PubMed] [Google Scholar]
  10. SCORER C. G. The incidence of incomplete descent of the testicle at birth. Arch Dis Child. 1956 Jun;31(157):198–202. doi: 10.1136/adc.31.157.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Walker A. H., Bernstein L., Warren D. W., Warner N. E., Zheng X., Henderson B. E. The effect of in utero ethinyl oestradiol exposure on the risk of cryptorchid testis and testicular teratoma in mice. Br J Cancer. 1990 Oct;62(4):599–602. doi: 10.1038/bjc.1990.337. [DOI] [PMC free article] [PubMed] [Google Scholar]

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