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. 1996 Feb;73(3):366–371. doi: 10.1038/bjc.1996.62

LOH at 3p correlates with a poor survival in oral squamous cell carcinoma.

M Partridge 1, G Emilion 1, J D Langdon 1
PMCID: PMC2074435  PMID: 8562343

Abstract

We analysed chromosome 3p for loss of heterozygosity (LOH) in 48 primary oral squamous cell carcinomas (SCCs) using 15 markers and constructed a deletion map for this chromosome arm. LOH at one or more loci was found in 34/48 (71%) of tumours. The data support the existence of at least three distinct regions of deletion at 3p24-26, 3p21.3-22.1 and 3p12.1-14.2. A significant correlation was observed between the number of regions showing allele loss at 3p and tumour stage, consistent with the progressive accumulation of genetic errors during the development of oral SCC. There were also significant associations between LOH at 3p and disease-free and overall survival of patients with early stage disease. This study is the first to demonstrate the prognostic significance of LOH at 3p for oral cancer and may help to identify patients who should receive more aggressive treatment.

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Selected References

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  1. Ah-See K. W., Cooke T. G., Pickford I. R., Soutar D., Balmain A. An allelotype of squamous carcinoma of the head and neck using microsatellite markers. Cancer Res. 1994 Apr 1;54(7):1617–1621. [PubMed] [Google Scholar]
  2. Carr R. J., Langdon J. D. Multiple primaries in mouth cancer--the price of success. Br J Oral Maxillofac Surg. 1989 Oct;27(5):394–399. doi: 10.1016/0266-4356(89)90079-x. [DOI] [PubMed] [Google Scholar]
  3. Chen L. C., Matsumura K., Deng G., Kurisu W., Ljung B. M., Lerman M. I., Waldman F. M., Smith H. S. Deletion of two separate regions on chromosome 3p in breast cancers. Cancer Res. 1994 Jun 1;54(11):3021–3024. [PubMed] [Google Scholar]
  4. Fearon E. R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990 Jun 1;61(5):759–767. doi: 10.1016/0092-8674(90)90186-i. [DOI] [PubMed] [Google Scholar]
  5. Hibi K., Takahashi T., Yamakawa K., Ueda R., Sekido Y., Ariyoshi Y., Suyama M., Takagi H., Nakamura Y., Takahashi T. Three distinct regions involved in 3p deletion in human lung cancer. Oncogene. 1992 Mar;7(3):445–449. [PubMed] [Google Scholar]
  6. Jones M. H., Nakamura Y. Deletion mapping of chromosome 3p in female genital tract malignancies using microsatellite polymorphisms. Oncogene. 1992 Aug;7(8):1631–1634. [PubMed] [Google Scholar]
  7. Kohno T., Takayama H., Hamaguchi M., Takano H., Yamaguchi N., Tsuda H., Hirohashi S., Vissing H., Shimizu M., Oshimura M. Deletion mapping of chromosome 3p in human uterine cervical cancer. Oncogene. 1993 Jul;8(7):1825–1832. [PubMed] [Google Scholar]
  8. LaForgia S., Morse B., Levy J., Barnea G., Cannizzaro L. A., Li F., Nowell P. C., Boghosian-Sell L., Glick J., Weston A. Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):5036–5040. doi: 10.1073/pnas.88.11.5036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Li X., Lee N. K., Ye Y. W., Waber P. G., Schweitzer C., Cheng Q. C., Nisen P. D. Allelic loss at chromosomes 3p, 8p, 13q, and 17p associated with poor prognosis in head and neck cancer. J Natl Cancer Inst. 1994 Oct 19;86(20):1524–1529. doi: 10.1093/jnci/86.20.1524. [DOI] [PubMed] [Google Scholar]
  10. Mattei M. G., de Thé H., Mattei J. F., Marchio A., Tiollais P., Dejean A. Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3. Hum Genet. 1988 Oct;80(2):189–190. doi: 10.1007/BF00702867. [DOI] [PubMed] [Google Scholar]
  11. Nawroz H., van der Riet P., Hruban R. H., Koch W., Ruppert J. M., Sidransky D. Allelotype of head and neck squamous cell carcinoma. Cancer Res. 1994 Mar 1;54(5):1152–1155. [PubMed] [Google Scholar]
  12. Partridge M., Kiguwa S., Langdon J. D. Frequent deletion of chromosome 3p in oral squamous cell carcinoma. Eur J Cancer B Oral Oncol. 1994 Jul;30B(4):248–251. doi: 10.1016/0964-1955(94)90006-x. [DOI] [PubMed] [Google Scholar]
  13. Sanchez Y., el-Naggar A., Pathak S., Killary A. M. A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3383–3387. doi: 10.1073/pnas.91.8.3383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Shuin T., Kondo K., Torigoe S., Kishida T., Kubota Y., Hosaka M., Nagashima Y., Kitamura H., Latif F., Zbar B. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res. 1994 Jun 1;54(11):2852–2855. [PubMed] [Google Scholar]
  15. Sundaresan V., Ganly P., Hasleton P., Rudd R., Sinha G., Bleehen N. M., Rabbitts P. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene. 1992 Oct;7(10):1989–1997. [PubMed] [Google Scholar]
  16. Wu C. L., Sloan P., Read A. P., Harris R., Thakker N. Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma of the oral cavity. Cancer Res. 1994 Dec 15;54(24):6484–6488. [PubMed] [Google Scholar]
  17. Yokota J., Tsukada Y., Nakajima T., Gotoh M., Shimosato Y., Mori N., Tsunokawa Y., Sugimura T., Terada M. Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix. Cancer Res. 1989 Jul 1;49(13):3598–3601. [PubMed] [Google Scholar]

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