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. 1996 Jul;74(1):152–158. doi: 10.1038/bjc.1996.331

Patterns of childhood cancer among siblings.

G J Draper 1, B M Sanders 1, E L Lennox 1, P A Brownbill 1
PMCID: PMC2074611  PMID: 8679450

Abstract

The National Registry of Childhood Tumours contains over 51000 records of children born in Great Britain who developed cancer under the age of 15 years. Patterns of childhood cancer among families containing more than one child with cancer have been studied. A total of 225 "sib pair' families have been ascertained from interviews with parents of affected children, from hospital and general practitioner records and from manual and computer searches of names and addresses of patients. A number of special groups have been identified, including those with a known genetic aetiology such as retinoblastoma, twins and families with three or more affected children. A further 148 families not in any of the above groups contain two children with cancer: in 46 families the children had tumours of the same type, most commonly leukaemia. Some of the families are examples of the Li-Fraumeni syndrome; some are associated with other conditions, including Down's syndrome. There is clearly a genetic element in the aetiology of cancer in some families discussed here; shared exposure to environmental causes may account for others and some will be simply due to chance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baird P. N., Pritchard J., Cowell J. K. Molecular genetic analysis of chromosome 11p in familial Wilms tumour. Br J Cancer. 1994 Jun;69(6):1072–1077. doi: 10.1038/bjc.1994.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bithell J. F., Stewart A. M. Pre-natal irradiation and childhood malignancy: a review of British data from the Oxford Survey. Br J Cancer. 1975 Mar;31(3):271–287. doi: 10.1038/bjc.1975.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Breslow N., Beckwith J. B., Ciol M., Sharples K. Age distribution of Wilms' tumor: report from the National Wilms' Tumor Study. Cancer Res. 1988 Mar 15;48(6):1653–1657. [PubMed] [Google Scholar]
  4. Chaganti R. S., Miller D. R., Meyers P. A., German J. Cytogenetic evidence of the intrauterine origin of acute leukemia in monozygotic twins. N Engl J Med. 1979 May 3;300(18):1032–1034. doi: 10.1056/NEJM197905033001807. [DOI] [PubMed] [Google Scholar]
  5. Draper G. J., Heaf M. M., Kinnier Wilson L. M. Occurrence of childhood cancers among sibs and estimation of familial risks. J Med Genet. 1977 Apr;14(2):81–90. doi: 10.1136/jmg.14.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Draper G. J., Sanders B. M., Brownbill P. A., Hawkins M. M. Patterns of risk of hereditary retinoblastoma and applications to genetic counselling. Br J Cancer. 1992 Jul;66(1):211–219. doi: 10.1038/bjc.1992.244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Eng C., Li F. P., Abramson D. H., Ellsworth R. M., Wong F. L., Goldman M. B., Seddon J., Tarbell N., Boice J. D., Jr Mortality from second tumors among long-term survivors of retinoblastoma. J Natl Cancer Inst. 1993 Jul 21;85(14):1121–1128. doi: 10.1093/jnci/85.14.1121. [DOI] [PubMed] [Google Scholar]
  8. Ford A. M., Ridge S. A., Cabrera M. E., Mahmoud H., Steel C. M., Chan L. C., Greaves M. In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Nature. 1993 May 27;363(6427):358–360. doi: 10.1038/363358a0. [DOI] [PubMed] [Google Scholar]
  9. Green D. M. Childhood cancer in siblings. Pediatr Hematol Oncol. 1986;3(3):229–239. doi: 10.3109/08880018609031222. [DOI] [PubMed] [Google Scholar]
  10. Knudson A. G., Jr, Strong L. C. Mutation and cancer: a model for Wilms' tumor of the kidney. J Natl Cancer Inst. 1972 Feb;48(2):313–324. [PubMed] [Google Scholar]
  11. Knudson A. G., Jr, Strong L. C. Mutation and cancer: neuroblastoma and pheochromocytoma. Am J Hum Genet. 1972 Sep;24(5):514–532. [PMC free article] [PubMed] [Google Scholar]
  12. Li F. P., Fraumeni J. F., Jr, Mulvihill J. J., Blattner W. A., Dreyfus M. G., Tucker M. A., Miller R. W. A cancer family syndrome in twenty-four kindreds. Cancer Res. 1988 Sep 15;48(18):5358–5362. [PubMed] [Google Scholar]
  13. Li F. P., Fraumeni J. F., Jr Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med. 1969 Oct;71(4):747–752. doi: 10.7326/0003-4819-71-4-747. [DOI] [PubMed] [Google Scholar]
  14. Li F. P., Tucker M. A., Fraumeni J. F., Jr Childhood cancer in sibs. J Pediatr. 1976 Mar;88(3):419–423. doi: 10.1016/s0022-3476(76)80256-9. [DOI] [PubMed] [Google Scholar]
  15. Mann J. R., Corkery J. J., Fisher H. J., Cameron A. H., Mayerová A., Wolf U., Kennaugh A. A., Woolley V. The X linked recessive form of XY gonadal dysgenesis with a high incidence of gonadal germ cell tumours: clinical and genetic studies. J Med Genet. 1983 Aug;20(4):264–270. doi: 10.1136/jmg.20.4.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Miller R. W. Deaths from childhood leukemia and solid tumors among twins and other sibs in the United States, 1960-67. J Natl Cancer Inst. 1971 Jan;46(1):203–209. [PubMed] [Google Scholar]
  17. STEWART A., WEBB J., HEWITT D. A survey of childhood malignancies. Br Med J. 1958 Jun 28;1(5086):1495–1508. doi: 10.1136/bmj.1.5086.1495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sanders B. M., Jay M., Draper G. J., Roberts E. M. Non-ocular cancer in relatives of retinoblastoma patients. Br J Cancer. 1989 Sep;60(3):358–365. doi: 10.1038/bjc.1989.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Stiller C. A., Allen M. B., Eatock E. M. Childhood cancer in Britain: the National Registry of Childhood Tumours and incidence rates 1978-1987. Eur J Cancer. 1995 Nov;31A(12):2028–2034. doi: 10.1016/0959-8049(95)00428-9. [DOI] [PubMed] [Google Scholar]
  20. Stiller C. A., Chessells J. M., Fitchett M. Neurofibromatosis and childhood leukaemia/lymphoma: a population-based UKCCSG study. Br J Cancer. 1994 Nov;70(5):969–972. doi: 10.1038/bjc.1994.431. [DOI] [PMC free article] [PubMed] [Google Scholar]

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