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. 1996 Oct;74(8):1321–1323. doi: 10.1038/bjc.1996.538

Incidence of invasive cancers following carcinoma in situ of the cervix.

F Levi 1, L Randimbison 1, C La Vecchia 1, S Franceschi 1
PMCID: PMC2075928  PMID: 8883426

Abstract

Women with carcinoma in situ (CIS) of the cervix uteri, notified to the population-based Cancer Registry of the Swiss Canton of Vaud between 1974 and 1993, were actively followed up to 31 December 1993 for the occurrence of subsequent invasive neoplasms. Among 2190 incident cases of CIS, followed for a total of 22,225 person-years, 95 metachronous cancers were observed vs 77.9 expected, corresponding to a significant standardised incidence ratio (SIR) of 1.2. Ten cases of invasive cervical cancer were observed vs 3.0 expected (SIR = 3.4, P < 0.01), the excess being larger in the first 10 years since CIS diagnosis. A total of 11 cases of four major tobacco-related sites (lung, mouth or pharynx, oesophagus and urinary bladder) were observed vs 5.1 expected, corresponding to a significant SIR of 2.2. The excess was observed > or = 10 years after CIS diagnosis. There was also an excess of non-melanomatous skin cancers (29 observed, 16.9 expected, SIR = 1.7; P < 0.01), but not of skin melanoma and of any of the other neoplasms considered, including breast and corpus uteri. This population-based study, therefore, finds an excess of invasive cervical cancer in the short term after CIS diagnosis, and a medium- to long-term excess risk of tobacco-related and non-melanomatous skin neoplasms. These findings are discussed in terms of increased surveillance and case ascertainment after CIS, and of potential shared risk factors (tobacco and/or viral infections).

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Selected References

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  1. Benamouzig R., Pigot F., Quiroga G., Validire P., Chaussade S., Catalan F., Couturier D. Human papillomavirus infection in esophageal squamous-cell carcinoma in western countries. Int J Cancer. 1992 Feb 20;50(4):549–552. doi: 10.1002/ijc.2910500409. [DOI] [PubMed] [Google Scholar]
  2. Bjørge T., Hennig E. M., Skare G. B., Søreide O., Thoresen S. O. Second primary cancers in patients with carcinoma in situ of the uterine cervix. The Norwegian experience 1970-1992. Int J Cancer. 1995 Jul 4;62(1):29–33. doi: 10.1002/ijc.2910620108. [DOI] [PubMed] [Google Scholar]
  3. Gissmann L., Wolnik L., Ikenberg H., Koldovsky U., Schnürch H. G., zur Hausen H. Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci U S A. 1983 Jan;80(2):560–563. doi: 10.1073/pnas.80.2.560. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hartveit F. Association of skin and other lesions with cervical dysplasia. Oncology. 1988;45(2):103–106. doi: 10.1159/000226542. [DOI] [PubMed] [Google Scholar]
  5. Hellberg D., Nilsson S., Haley N. J., Hoffman D., Wynder E. Smoking and cervical intraepithelial neoplasia: nicotine and cotinine in serum and cervical mucus in smokers and nonsmokers. Am J Obstet Gynecol. 1988 Apr;158(4):910–913. doi: 10.1016/0002-9378(88)90093-2. [DOI] [PubMed] [Google Scholar]
  6. La Vecchia C., Levi F., Franceschi S. Screening for cancer, 1995: an update. Ann Oncol. 1995 Jul;6(6):537–541. doi: 10.1093/oxfordjournals.annonc.a059241. [DOI] [PubMed] [Google Scholar]
  7. Levi F., La Vecchia C., Randimbison L., Franceschi S. Incidence of infiltrating cancer following superficial bladder carcinoma. Int J Cancer. 1993 Sep 30;55(3):419–421. doi: 10.1002/ijc.2910550316. [DOI] [PubMed] [Google Scholar]
  8. Levi F., Randimbison L., Te V. C., Rolland-Portal I., Franceschi S., La Vecchia C. Multiple primary cancers in the Vaud Cancer Registry, Switzerland, 1974-89. Br J Cancer. 1993 Feb;67(2):391–395. doi: 10.1038/bjc.1993.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Maden C., Beckmann A. M., Thomas D. B., McKnight B., Sherman K. J., Ashley R. L., Corey L., Daling J. R. Human papillomaviruses, herpes simplex viruses, and the risk of oral cancer in men. Am J Epidemiol. 1992 May 15;135(10):1093–1102. doi: 10.1093/oxfordjournals.aje.a116209. [DOI] [PubMed] [Google Scholar]
  10. McCann M. F., Irwin D. E., Walton L. A., Hulka B. S., Morton J. L., Axelrad C. M. Nicotine and cotinine in the cervical mucus of smokers, passive smokers, and nonsmokers. Cancer Epidemiol Biomarkers Prev. 1992 Jan-Feb;1(2):125–129. [PubMed] [Google Scholar]
  11. Parazzini F., La Vecchia C., Negri E., Fedele L., Franceschi S., Gallotta L. Risk factors for cervical intraepithelial neoplasia. Cancer. 1992 May 1;69(9):2276–2282. doi: 10.1002/1097-0142(19920501)69:9<2276::aid-cncr2820690912>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  12. Rabkin C. S., Biggar R. J., Melbye M., Curtis R. E. Second primary cancers following anal and cervical carcinoma: evidence of shared etiologic factors. Am J Epidemiol. 1992 Jul 1;136(1):54–58. doi: 10.1093/oxfordjournals.aje.a116420. [DOI] [PubMed] [Google Scholar]
  13. Schiffman M. H., Haley N. J., Felton J. S., Andrews A. W., Kaslow R. A., Lancaster W. D., Kurman R. J., Brinton L. A., Lannom L. B., Hoffmann D. Biochemical epidemiology of cervical neoplasia: measuring cigarette smoke constituents in the cervix. Cancer Res. 1987 Jul 15;47(14):3886–3888. [PubMed] [Google Scholar]
  14. Shmulewitz E. Y., Weiss N. S., Schwartz S. M. Cutaneous melanoma following cervical intra-epithelial neoplasia in western Washington State. Cancer Causes Control. 1993 May;4(3):225–229. doi: 10.1007/BF00051317. [DOI] [PubMed] [Google Scholar]
  15. Storm H. H., Ewertz M. Second cancer following cancer of the female genital system in Denmark, 1943-80. Natl Cancer Inst Monogr. 1985 Dec;68:331–340. [PubMed] [Google Scholar]
  16. Storm H. H. Second primary cancer after treatment for cervical cancer. Late effects after radiotherapy. Cancer. 1988 Feb 15;61(4):679–688. doi: 10.1002/1097-0142(19880215)61:4<679::aid-cncr2820610411>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  17. Szarewski A., Jarvis M. J., Sasieni P., Anderson M., Edwards R., Steele S. J., Guillebaud J., Cuzick J. Effect of smoking cessation on cervical lesion size. Lancet. 1996 Apr 6;347(9006):941–943. doi: 10.1016/s0140-6736(96)91417-8. [DOI] [PubMed] [Google Scholar]
  18. Winkelstein W., Jr Smoking and cancer of the uterine cervix: hypothesis. Am J Epidemiol. 1977 Oct;106(4):257–259. doi: 10.1093/oxfordjournals.aje.a112460. [DOI] [PubMed] [Google Scholar]
  19. Winkelstein W., Jr Smoking and cervical cancer--current status: a review. Am J Epidemiol. 1990 Jun;131(6):945–960. doi: 10.1093/oxfordjournals.aje.a115614. [DOI] [PubMed] [Google Scholar]

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