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. 1996 Oct;74(7):1104–1108. doi: 10.1038/bjc.1996.497

Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.

R Sud 1, I C Talbot 1, J D Delhanty 1
PMCID: PMC2077127  PMID: 8855982

Abstract

We examined 26 gastric carcinomas from British patients for mutations of the APC gene using a single-strand conformation polymorphism (SSCP) and heteroduplex assay in conjunction with the protein truncation test (PTT). In addition, we performed loss of heterozygosity (LOH) analysis of the APC and MCC genes. We detected an inactivating somatic mutation in one gastric tumour. LOH of APC was observed in one of 12 informative cases (8%) and of MCC in two of 20 cases (10%). We thus find that alteration of the APC and MCC genes are infrequent in gastric cancers from the British population. Tumour-suppressor genes on other chromosomes must play a more significant role in the development of these tumours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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