Skip to main content
PMC home page
The Journal of Hygiene logoLink to The Journal of Hygiene
. 1986 Oct;97(2):369–375. doi: 10.1017/s0022172400065451

The antigenic analysis of haemorrhagic fever with renal syndrome viruses in China by monoclonal antibodies.

Z K Xu, X L An, M X Wang
PMCID: PMC2083549  PMID: 2878042

Abstract

Thirty-six strains of haemorrhagic fever with renal syndrome (HFRS) virus were isolated from patients and a number of host animals in various areas in China. They were analysed by an immunofluorescence test (IFAT) using 10 monoclonal antibodies (McAbs) specific for the HFRS virus; antigenic differences among the strains have been demonstrated. The HFRS virus strains revealed nine different reactions with the McAbs, showing that there are at least nine different antigenic determinants including group-, type- and strain-specific. Analysis of the results shows that antigenic differences among the HFRS virus strains are mainly related to differences in the host animals.

Full text

PDF
370

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Franko M. C., Gibbs C. J., Jr, Lee P. W., Gajdusek D. C. Monoclonal antibodies specific for Hantaan virus. Proc Natl Acad Sci U S A. 1983 Jul;80(13):4149–4153. doi: 10.1073/pnas.80.13.4149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Goldgaber D., Gibbs C. J., Jr, Gajdusek D. C., Svedmyr A. Definition of three serotypes of Hantaviruses by a double sandwich ELISA with biotin-avidin amplification system. J Gen Virol. 1985 Aug;66(Pt 8):1733–1740. doi: 10.1099/0022-1317-66-8-1733. [DOI] [PubMed] [Google Scholar]
  3. Hung T., Xia S. M., Zhao T. X., Zhou J. Y., Song G., Liao G. X., Ye W. W., Chu Y. L., Hang C. S. Morphological evidence for identifying the viruses of hemorrhagic fever with renal syndrome as candidate members of the Bunyaviridae family. Brief report. Arch Virol. 1983;78(1-2):137–144. doi: 10.1007/BF01310869. [DOI] [PubMed] [Google Scholar]
  4. Lee H. W., Lee P. W., Johnson K. M. Isolation of the etiologic agent of Korean Hemorrhagic fever. J Infect Dis. 1978 Mar;137(3):298–308. doi: 10.1093/infdis/137.3.298. [DOI] [PubMed] [Google Scholar]
  5. Lee P. W., Gibbs C. J., Jr, Gajdusek D. C., Yanagihara R. Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests. J Clin Microbiol. 1985 Dec;22(6):940–944. doi: 10.1128/jcm.22.6.940-944.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Li Z. L. [Detection of the viral antigen of hemorrhagic fever with renal syndrome (HFRS) in Apodemus species]. Zhonghua Liu Xing Bing Xue Za Zhi. 1983 Aug;4(4):205–206. [PubMed] [Google Scholar]
  7. Ni D. S. [Identification of a strain of epidemic hemorrhagic fever (EHF) virus from patients' sera]. Zhonghua Yi Xue Za Zhi. 1983 Feb;63(2):65–68. [PubMed] [Google Scholar]
  8. Schmaljohn C. S., Hasty S. E., Dalrymple J. M., LeDuc J. W., Lee H. W., von Bonsdorff C. H., Brummer-Korvenkontio M., Vaheri A., Tsai T. F., Regnery H. L. Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome. Science. 1985 Mar 1;227(4690):1041–1044. doi: 10.1126/science.2858126. [DOI] [PubMed] [Google Scholar]
  9. Song G., Qiu X. Z., Ni D. S., Zhao J. N., Kong B. X. [Etiological studies of epidemic hemorrhagic fever. I. Virus isolation in Apodemus agrarius from non-endemic area and its antigenic characterization]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1982;4(2):73–77. [PubMed] [Google Scholar]
  10. Xu C. W. [Epidemiological investigation on an outbreak of mild type of hemorrhagic fever]. Zhonghua Liu Xing Bing Xue Za Zhi. 1982 Aug;3(4):201–203. [PubMed] [Google Scholar]
  11. Yan Y. C. [Preliminary investigation on the etiology and host animals of epidemic hemorrhagic fever in Honan]. Zhonghua Liu Xing Bing Xue Za Zhi. 1982 Aug;3(4):197–200. [PubMed] [Google Scholar]

Articles from The Journal of Hygiene are provided here courtesy of Cambridge University Press

RESOURCES