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. 1990 Feb;172(2):1137–1141. doi: 10.1128/jb.172.2.1137-1141.1990

Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium.

Y F Zhu 1, I H Curran 1, B Joris 1, J M Ghuysen 1, J O Lampen 1
PMCID: PMC208548  PMID: 2404938

Abstract

The blaR gene of Bacillus licheniformis encodes the signal transducer for induction of the class A beta-lactamase. The protein product, BlaR, has a hydrophilic carboxy region that binds beta-lactams and shows high sequence homology to the class D beta-lactamases, particularly the OXA-2 beta-lactamase of Salmonella typhimurium. The BlaR-beta-lactam complex is stable and may provide the continuing stimulus needed for the prolonged production of the enzyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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