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. 1989 Feb;171(2):1028–1034. doi: 10.1128/jb.171.2.1028-1034.1989

Genetic characterization of frameshift suppressors with new decoding properties.

D Hughes 1, S Thompson 1, M O'Connor 1, T Tuohy 1, B P Nichols 1, J F Atkins 1
PMCID: PMC209697  PMID: 2644219

Abstract

Suppressor mutants that cause ribosomes to shift reading frame at specific and new sequences are described. Suppressors for trpE91, the only known suppressible -1 frameshift mutant, have been isolated in Escherichia coli and in Salmonella typhimurium. E. coli hopR acts on trpE91 within the 9-base-pair sequence GGA GUG UGA, is dominant, and is located at min 52 on the chromosome. Its Salmonella homolog maps at an equivalent position and arises as a rarer class in that organism as compared with E. coli. The Salmonella suppressor, hopE, believed to be in a duplicate copy of the same gene, maps at min 17. The +1 suppressor, sufT, acts at the nonmonotonous sequence CCGU, is dominant, and maps at min 59 on the Salmonella chromosome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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