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. 1989 Jun;171(6):3068–3073. doi: 10.1128/jb.171.6.3068-3073.1989

Bacteriophage association of streptococcal pyrogenic exotoxin type C.

S C Goshorn 1, P M Schlievert 1
PMCID: PMC210016  PMID: 2566595

Abstract

A gene encoding streptococcal pyrogenic exotoxin type C (SPE C) was isolated from bacteriophage DNA derived from Streptococcus pyogenes CS112. The gene, designated speC2, was shown to reside near the phage attachment site of phage CS112. A restriction endonuclease map of the CS112 phage was generated, and the location and orientation of the speC2 gene were determined. Hybridization analyses of eight SPE C-producing strains revealed restriction fragment length polymorphism of the speC gene-containing DNA fragments and further showed that each speC was linked to a common CS112 phage-derived DNA fragment.

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