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. 1989 Dec;171(12):6517–6520. doi: 10.1128/jb.171.12.6517-6520.1989

Genetic selection and DNA sequences of 4.5S RNA homologs.

S Brown 1, G Thon 1, E Tolentino 1
PMCID: PMC210541  PMID: 2512280

Abstract

A general strategy for cloning the functional homologs of an Escherichia coli gene was used to clone homologs of 4.5S RNA from other bacteria. The genes encoding these homologs were selected by their ability to complement a deletion of the gene for 4.5S RNA. DNA sequences of the regions encoding the homologs were determined. Since this approach does not require that the homologous genes hybridize with probes generated from the E. coli sequence, the sequences of the homologs were not all similar to the sequence of the E. coli gene. Despite the dissimilarity of the primary sequences of some of the homologs, all could be folded to obtain a similar structure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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