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. 1988 Aug;170(8):3756–3760. doi: 10.1128/jb.170.8.3756-3760.1988

Is efficiency of suppressor tRNAs controlled at the level of ribosomal proofreading in vivo?

M Faxén 1, L A Kirsebom 1, L A Isaksson 1
PMCID: PMC211358  PMID: 3042761

Abstract

Ribosomal rpsD mutations did not stimulate nonsense suppressor tRNAs in a general manner according to their increased ribosomal ambiguity and decreased proofreading efficiency. Streptomycin, which stimulates error production by blocking proofreading in vitro, did not increase efficiency of suppressor tRNAs in strains with normal or streptomycin-resistant (rpsL) ribosomes. It did so only in combination with one rpsL mutation which is associated with streptomycin pseudodependence.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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