Full Text
The Full Text of this article is available as a PDF (685.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson J. M., Stevenson B. R., Jesaitis L. A., Goodenough D. A., Mooseker M. S. Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells. J Cell Biol. 1988 Apr;106(4):1141–1149. doi: 10.1083/jcb.106.4.1141. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Anderson J. M., Van Itallie C. M., Peterson M. D., Stevenson B. R., Carew E. A., Mooseker M. S. ZO-1 mRNA and protein expression during tight junction assembly in Caco-2 cells. J Cell Biol. 1989 Sep;109(3):1047–1056. doi: 10.1083/jcb.109.3.1047. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Behrens J., Birchmeier W., Goodman S. L., Imhof B. A. Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin. J Cell Biol. 1985 Oct;101(4):1307–1315. doi: 10.1083/jcb.101.4.1307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bennett V. Ankyrins. Adaptors between diverse plasma membrane proteins and the cytoplasm. J Biol Chem. 1992 May 5;267(13):8703–8706. [PubMed] [Google Scholar]
- Boller K., Vestweber D., Kemler R. Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells. J Cell Biol. 1985 Jan;100(1):327–332. doi: 10.1083/jcb.100.1.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Byers S. W., Citi S., Anderson J. M., Hoxter B. Polarized functions and permeability properties of rat epididymal epithelial cells in vitro. J Reprod Fertil. 1992 Jul;95(2):385–396. doi: 10.1530/jrf.0.0950385. [DOI] [PubMed] [Google Scholar]
- Citi S., Amorosi A., Franconi F., Giotti A., Zampi G. Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues. Am J Pathol. 1991 Apr;138(4):781–789. [PMC free article] [PubMed] [Google Scholar]
- Citi S. Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells. J Cell Biol. 1992 Apr;117(1):169–178. doi: 10.1083/jcb.117.1.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Citi S., Sabanay H., Jakes R., Geiger B., Kendrick-Jones J. Cingulin, a new peripheral component of tight junctions. Nature. 1988 May 19;333(6170):272–276. doi: 10.1038/333272a0. [DOI] [PubMed] [Google Scholar]
- Citi S., Sabanay H., Kendrick-Jones J., Geiger B. Cingulin: characterization and localization. J Cell Sci. 1989 May;93(Pt 1):107–122. doi: 10.1242/jcs.93.1.107. [DOI] [PubMed] [Google Scholar]
- Collins J. E., Legan P. K., Kenny T. P., MacGarvie J., Holton J. L., Garrod D. R. Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains. J Cell Biol. 1991 Apr;113(2):381–391. doi: 10.1083/jcb.113.2.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Diamond J. M. Twenty-first Bowditch lecture. The epithelial junction: bridge, gate, and fence. Physiologist. 1977 Feb;20(1):10–18. [PubMed] [Google Scholar]
- Drenckhahn D., Dermietzel R. Organization of the actin filament cytoskeleton in the intestinal brush border: a quantitative and qualitative immunoelectron microscope study. J Cell Biol. 1988 Sep;107(3):1037–1048. doi: 10.1083/jcb.107.3.1037. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FARQUHAR M. G., PALADE G. E. Junctional complexes in various epithelia. J Cell Biol. 1963 May;17:375–412. doi: 10.1083/jcb.17.2.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fleming T. P., McConnell J., Johnson M. H., Stevenson B. R. Development of tight junctions de novo in the mouse early embryo: control of assembly of the tight junction-specific protein, ZO-1. J Cell Biol. 1989 Apr;108(4):1407–1418. doi: 10.1083/jcb.108.4.1407. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Geiger B., Ayalon O. Cadherins. Annu Rev Cell Biol. 1992;8:307–332. doi: 10.1146/annurev.cb.08.110192.001515. [DOI] [PubMed] [Google Scholar]
- Geiger B., Volk T., Volberg T. Molecular heterogeneity of adherens junctions. J Cell Biol. 1985 Oct;101(4):1523–1531. doi: 10.1083/jcb.101.4.1523. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goodenough D. A., Revel J. P. A fine structural analysis of intercellular junctions in the mouse liver. J Cell Biol. 1970 May;45(2):272–290. doi: 10.1083/jcb.45.2.272. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Griepp E. B., Dolan W. J., Robbins E. S., Sabatini D. D. Participation of plasma membrane proteins in the formation of tight junctions by cultured epithelial cells. J Cell Biol. 1983 Mar;96(3):693–702. doi: 10.1083/jcb.96.3.693. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gumbiner B., Lowenkopf T., Apatira D. Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3460–3464. doi: 10.1073/pnas.88.8.3460. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gumbiner B., Simons K. A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J Cell Biol. 1986 Feb;102(2):457–468. doi: 10.1083/jcb.102.2.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gumbiner B., Stevenson B., Grimaldi A. The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J Cell Biol. 1988 Oct;107(4):1575–1587. doi: 10.1083/jcb.107.4.1575. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gumbiner B. Structure, biochemistry, and assembly of epithelial tight junctions. Am J Physiol. 1987 Dec;253(6 Pt 1):C749–C758. doi: 10.1152/ajpcell.1987.253.6.C749. [DOI] [PubMed] [Google Scholar]
- Hirokawa N. The intramembrane structure of tight junctions: an experimental analysis of the single-fibril and two-fibril models using the quick-freeze method. J Ultrastruct Res. 1982 Sep;80(3):288–301. doi: 10.1016/s0022-5320(82)80042-7. [DOI] [PubMed] [Google Scholar]
- Howarth A. G., Hughes M. R., Stevenson B. R. Detection of the tight junction-associated protein ZO-1 in astrocytes and other nonepithelial cell types. Am J Physiol. 1992 Feb;262(2 Pt 1):C461–C469. doi: 10.1152/ajpcell.1992.262.2.C461. [DOI] [PubMed] [Google Scholar]
- Hyafil F., Babinet C., Jacob F. Cell-cell interactions in early embryogenesis: a molecular approach to the role of calcium. Cell. 1981 Nov;26(3 Pt 1):447–454. doi: 10.1016/0092-8674(81)90214-2. [DOI] [PubMed] [Google Scholar]
- Itoh M., Nagafuchi A., Yonemura S., Kitani-Yasuda T., Tsukita S., Tsukita S. The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol. 1993 May;121(3):491–502. doi: 10.1083/jcb.121.3.491. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Itoh M., Yonemura S., Nagafuchi A., Tsukita S., Tsukita S. A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites. J Cell Biol. 1991 Dec;115(5):1449–1462. doi: 10.1083/jcb.115.5.1449. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kachar B., Reese T. S. Evidence for the lipidic nature of tight junction strands. Nature. 1982 Apr 1;296(5856):464–466. doi: 10.1038/296464a0. [DOI] [PubMed] [Google Scholar]
- Kemler R., Babinet C., Eisen H., Jacob F. Surface antigen in early differentiation. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4449–4452. doi: 10.1073/pnas.74.10.4449. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kobayashi T., Storrie B., Simons K., Dotti C. G. A functional barrier to movement of lipids in polarized neurons. Nature. 1992 Oct 15;359(6396):647–650. doi: 10.1038/359647a0. [DOI] [PubMed] [Google Scholar]
- Koch P. J., Walsh M. J., Schmelz M., Goldschmidt M. D., Zimbelmann R., Franke W. W. Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules. Eur J Cell Biol. 1990 Oct;53(1):1–12. [PubMed] [Google Scholar]
- Kurihara H., Anderson J. M., Farquhar M. G. Diversity among tight junctions in rat kidney: glomerular slit diaphragms and endothelial junctions express only one isoform of the tight junction protein ZO-1. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7075–7079. doi: 10.1073/pnas.89.15.7075. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Madara J. L. Intestinal absorptive cell tight junctions are linked to cytoskeleton. Am J Physiol. 1987 Jul;253(1 Pt 1):C171–C175. doi: 10.1152/ajpcell.1987.253.1.C171. [DOI] [PubMed] [Google Scholar]
- McNeill H., Ozawa M., Kemler R., Nelson W. J. Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell. 1990 Jul 27;62(2):309–316. doi: 10.1016/0092-8674(90)90368-o. [DOI] [PubMed] [Google Scholar]
- Mechanic S., Raynor K., Hill J. E., Cowin P. Desmocollins form a distinct subset of the cadherin family of cell adhesion molecules. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4476–4480. doi: 10.1073/pnas.88.10.4476. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mege R. M., Matsuzaki F., Gallin W. J., Goldberg J. I., Cunningham B. A., Edelman G. M. Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7274–7278. doi: 10.1073/pnas.85.19.7274. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morrow J. S., Cianci C. D., Ardito T., Mann A. S., Kashgarian M. Ankyrin links fodrin to the alpha subunit of Na,K-ATPase in Madin-Darby canine kidney cells and in intact renal tubule cells. J Cell Biol. 1989 Feb;108(2):455–465. doi: 10.1083/jcb.108.2.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nagafuchi A., Shirayoshi Y., Okazaki K., Yasuda K., Takeichi M. Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature. 1987 Sep 24;329(6137):341–343. doi: 10.1038/329341a0. [DOI] [PubMed] [Google Scholar]
- Nelson W. J., Hammerton R. W. A membrane-cytoskeletal complex containing Na+,K+-ATPase, ankyrin, and fodrin in Madin-Darby canine kidney (MDCK) cells: implications for the biogenesis of epithelial cell polarity. J Cell Biol. 1989 Mar;108(3):893–902. doi: 10.1083/jcb.108.3.893. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nelson W. J., Shore E. M., Wang A. Z., Hammerton R. W. Identification of a membrane-cytoskeletal complex containing the cell adhesion molecule uvomorulin (E-cadherin), ankyrin, and fodrin in Madin-Darby canine kidney epithelial cells. J Cell Biol. 1990 Feb;110(2):349–357. doi: 10.1083/jcb.110.2.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nelson W. J., Veshnock P. J. Ankyrin binding to (Na+ + K+)ATPase and implications for the organization of membrane domains in polarized cells. Nature. 1987 Aug 6;328(6130):533–536. doi: 10.1038/328533a0. [DOI] [PubMed] [Google Scholar]
- Ozawa M., Baribault H., Kemler R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711–1717. doi: 10.1002/j.1460-2075.1989.tb03563.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pinto da Silva P., Kachar B. On tight-junction structure. Cell. 1982 Mar;28(3):441–450. doi: 10.1016/0092-8674(82)90198-2. [DOI] [PubMed] [Google Scholar]
- Rabito C. A. Occluding junctions in a renal cell line (LLC-PK1) with characteristics of proximal tubular cells. Am J Physiol. 1986 Apr;250(4 Pt 2):F734–F743. doi: 10.1152/ajprenal.1986.250.4.F734. [DOI] [PubMed] [Google Scholar]
- Raphael Y., Altschuler R. A. Reorganization of cytoskeletal and junctional proteins during cochlear hair cell degeneration. Cell Motil Cytoskeleton. 1991;18(3):215–227. doi: 10.1002/cm.970180307. [DOI] [PubMed] [Google Scholar]
- Rodriguez-Boulan E., Nelson W. J. Morphogenesis of the polarized epithelial cell phenotype. Science. 1989 Aug 18;245(4919):718–725. doi: 10.1126/science.2672330. [DOI] [PubMed] [Google Scholar]
- Sang U. H., Saier M. H., Jr, Ellisman M. H. Tight junction formation in the establishment of intramembranous particle polarity in aggregating MDCK cells. Effect of drug treatment. Exp Cell Res. 1980 Jul;128(1):223–235. doi: 10.1016/0014-4827(80)90406-1. [DOI] [PubMed] [Google Scholar]
- Schnabel E., Anderson J. M., Farquhar M. G. The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium. J Cell Biol. 1990 Sep;111(3):1255–1263. doi: 10.1083/jcb.111.3.1255. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schneeberger E. E., Lynch R. D. Structure, function, and regulation of cellular tight junctions. Am J Physiol. 1992 Jun;262(6 Pt 1):L647–L661. doi: 10.1152/ajplung.1992.262.6.L647. [DOI] [PubMed] [Google Scholar]
- Siliciano J. D., Goodenough D. A. Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells. J Cell Biol. 1988 Dec;107(6 Pt 1):2389–2399. doi: 10.1083/jcb.107.6.2389. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Staehelin L. A. Further observations on the fine structure of freeze-cleaved tight junctions. J Cell Sci. 1973 Nov;13(3):763–786. doi: 10.1242/jcs.13.3.763. [DOI] [PubMed] [Google Scholar]
- Stevenson B. R., Goodenough D. A. Zonulae occludentes in junctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterization. J Cell Biol. 1984 Apr;98(4):1209–1221. doi: 10.1083/jcb.98.4.1209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stevenson B. R., Heintzelman M. B., Anderson J. M., Citi S., Mooseker M. S. ZO-1 and cingulin: tight junction proteins with distinct identities and localizations. Am J Physiol. 1989 Oct;257(4 Pt 1):C621–C628. doi: 10.1152/ajpcell.1989.257.4.C621. [DOI] [PubMed] [Google Scholar]
- Stevenson B. R., Siliciano J. D., Mooseker M. S., Goodenough D. A. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol. 1986 Sep;103(3):755–766. doi: 10.1083/jcb.103.3.755. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Takeichi M. Cadherins: a molecular family important in selective cell-cell adhesion. Annu Rev Biochem. 1990;59:237–252. doi: 10.1146/annurev.bi.59.070190.001321. [DOI] [PubMed] [Google Scholar]
- Volk T., Geiger B. A-CAM: a 135-kD receptor of intercellular adherens junctions. I. Immunoelectron microscopic localization and biochemical studies. J Cell Biol. 1986 Oct;103(4):1441–1450. doi: 10.1083/jcb.103.4.1441. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wheeler G. N., Parker A. E., Thomas C. L., Ataliotis P., Poynter D., Arnemann J., Rutman A. J., Pidsley S. C., Watt F. M., Rees D. A. Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4796–4800. doi: 10.1073/pnas.88.11.4796. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Willott E., Balda M. S., Heintzelman M., Jameson B., Anderson J. M. Localization and differential expression of two isoforms of the tight junction protein ZO-1. Am J Physiol. 1992 May;262(5 Pt 1):C1119–C1124. doi: 10.1152/ajpcell.1992.262.5.C1119. [DOI] [PubMed] [Google Scholar]
- Zhong Y., Saitoh T., Minase T., Sawada N., Enomoto K., Mori M. Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2. J Cell Biol. 1993 Jan;120(2):477–483. doi: 10.1083/jcb.120.2.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van Deurs B., Luft J. H. Effects of glutaraldehyde fixation on the structure of tight junctions: a quantitative freeze-fracture analysis. J Ultrastruct Res. 1979 Aug;68(2):160–172. doi: 10.1016/s0022-5320(79)90151-5. [DOI] [PubMed] [Google Scholar]
- van Meer G., Gumbiner B., Simons K. The tight junction does not allow lipid molecules to diffuse from one epithelial cell to the next. Nature. 1986 Aug 14;322(6080):639–641. doi: 10.1038/322639a0. [DOI] [PubMed] [Google Scholar]