Skip to main content
The Journal of Hygiene logoLink to The Journal of Hygiene
. 1986 Apr;96(2):345–352. doi: 10.1017/s0022172400066092

Infection with influenza A H1N1. 2. The effect of past experience on natural challenge.

J R Davies, E A Grilli, A J Smith
PMCID: PMC2129641  PMID: 3701046

Abstract

Following its reintroduction in 1978 influenza A H1N1 spread widely in the child population. By the autumn of 1979, 75% of 11-year olds entering a boys' boarding school had detectable antibody. The protective effect of previous experience could be assessed during two outbreaks in the school. In the first outbreak in 1979, 90% of those known to have been infected in the previous year were protected against reinfection. In 1983 after strains of the H1N1 subtype had undergone antigenic drift a large outbreak occurred. It was estimated that past infection conferred protection against clinical influenza in 55%. Where past infection resulted in the presence of antibody which reacted with the outbreak strain the attack rate was further reduced. A large number of sub-clinical infections was detected in all groups.

Full text

PDF
350

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Al-Khayatt R., Jennings R., Potter C. W. Interpretation of responses and protective levels of antibody against attenuated influenza A viruses using single radial haemolysis. J Hyg (Lond) 1984 Oct;93(2):301–312. doi: 10.1017/s0022172400064834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Feery B. J., Gallichio H. A., Rodda S. J., Hampson A. W. Antibody responses to influenza vaccines containing A/USSR/90/77. Aust J Exp Biol Med Sci. 1979 Jun;57(3):335–344. doi: 10.1038/icb.1979.36. [DOI] [PubMed] [Google Scholar]
  3. Grilli E. A., Davies J. R., Smith A. J. Infection with influenza A H1N1. 1. Production and persistence of antibody. J Hyg (Lond) 1986 Apr;96(2):335–343. doi: 10.1017/s0022172400066080. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hoskins T. W., Davies J. R., Smith A. J., Miller C. L., Allchin A. Assessment of inactivated influenza-A vaccine after three outbreaks of influenza A at Christ's Hospital. Lancet. 1979 Jan 6;1(8106):33–35. doi: 10.1016/s0140-6736(79)90468-9. [DOI] [PubMed] [Google Scholar]
  5. Potter C. W., Clark A., Jennings R., Schild G. C., Wood J. M., McWilliams P. K. Reactogenicity and immunogenicity of inactivated influenza A (H1N1) virus vaccine in unprimed children. Report to the Medical Research Council Committee on influenza and other respiratory virus vaccines. J Biol Stand. 1980;8(1):35–48. doi: 10.1016/s0092-1157(80)80045-x. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Hygiene are provided here courtesy of Cambridge University Press

RESOURCES