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. 1976 Oct;77(2):271–282. doi: 10.1017/s0022172400024712

Natural infection with influenza A (H3N2). The development, persistance and effect of antibodies to the surface antigens.

A J Smith, J R Davies
PMCID: PMC2129857  PMID: 185291

Abstract

A technique for estimating antibodies to the neuraminidase antigens of influenza A is described. The antibody response to the haemagglutinin and neuraminidase antigens of influenza A (H3N2) was studied in a boys' public school over the four-year period 1970--4. During this time there were two outbreaks of influenza A and the effect of antibody on the result of natural challenge was investigated. No boy who had homotypic neuraminidase antibody had clinical influenza.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aymard-Henry M., Coleman M. T., Dowdle W. R., Laver W. G., Schild G. C., Webster R. G. Influenzavirus neuraminidase and neuraminidase-inhibition test procedures. Bull World Health Organ. 1973;48(2):199–202. [PMC free article] [PubMed] [Google Scholar]
  2. Couch R. B., Kasel J. A., Gerin J. L., Schulman J. L., Kilbourne E. D. Induction of partial immunity to influenza by a neuraminidase-specific vaccine. J Infect Dis. 1974 Apr;129(4):411–420. doi: 10.1093/infdis/129.4.411. [DOI] [PubMed] [Google Scholar]
  3. Dowdle W. R., Sarateanu D., Reimer C. B. Antiantibody enhancement of hemagglutination inhibition by influenza anti-neuraminidase. J Immunol. 1972 Dec;109(6):1321–1326. [PubMed] [Google Scholar]
  4. Hoskins T. W., Davies J. R., Smith A. J., Allchin A., Miller C. L., Pollock T. M. Influenza at Christ's Hospital: March, 1974. Lancet. 1976 Jan 17;1(7951):105–108. doi: 10.1016/s0140-6736(76)93151-2. [DOI] [PubMed] [Google Scholar]
  5. Murphy B. R., Kasel J. A., Chanock R. M. Association of serum anti-neuraminidase antibody with resistance to influenza in man. N Engl J Med. 1972 Jun 22;286(25):1329–1332. doi: 10.1056/NEJM197206222862502. [DOI] [PubMed] [Google Scholar]
  6. Schild G. C., Henry-Aymard M., Pereira H. G. A quantitative, single-radial-diffusion test for immunological studies with influenza virus. J Gen Virol. 1972 Aug;16(2):231–236. doi: 10.1099/0022-1317-16-2-231. [DOI] [PubMed] [Google Scholar]
  7. Slepushkin A. N., Schild G. C., Beare A. S., Chinn S., Tyrrell D. A. Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines. J Hyg (Lond) 1971 Dec;69(4):571–578. doi: 10.1017/s0022172400021847. [DOI] [PMC free article] [PubMed] [Google Scholar]

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