Skip to main content
PMC home page
The Journal of Hygiene logoLink to The Journal of Hygiene
. 1976 Oct;77(2):245–253. doi: 10.1017/s0022172400024670

Pathogenesis of foot-and-mouth disease: clearance of the virus from the circulation of cattle and goats during experimental viraemia.

P Sutmoller, J W McVicar
PMCID: PMC2129865  PMID: 185289

Abstract

Viraemia is an important aspect of the pathogenesis of infectious diseases, but the mechanisms of entry and removal of virus from the vascular system particularly in natural hosts are poorly understood. The results of this study showed that the clearance of foot and mouth disease virus (FMDV) from the circulation of cattle and goats followed the general rules for the clearance of inert particulate materials and other viruses from the circulation. High doses of infused FMDV were cleared less efficiently than low doses, probably as a result of a depletion of the reticulo-endothelial system by the higher doses. FMDV was cleared from the circulation of cattle at a considerably slower rate than from the circulation of goats, but in both species significant individual variation in clearance was observed. These results could explain individual as well as species variations relative to the onset and duration of viraemia.

Full text

PDF
246

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENACERRAF B., BIOZZI G., HALPERN B. N., STIFFEL C., MOUTON D. Phagocytosis of heat-denatured human serum albumin labelled with 131I and its use as a means of investigating liver blood flow. Br J Exp Pathol. 1957 Feb;38(1):35–48. [PMC free article] [PubMed] [Google Scholar]
  2. BIOZZI G., BENACERRAF B., HALPERN B. N. Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity. Br J Exp Pathol. 1953 Aug;34(4):441–457. [PMC free article] [PubMed] [Google Scholar]
  3. BRUNNER K. T., HUREZ D., McCLUSKEY R. T., BENACERRAF B. Blood clearance of P32-labeled vesicular stomatitis and Newcastle disease viruses by the reticuloendothelial system in mice. J Immunol. 1960 Jul;85:99–105. [PubMed] [Google Scholar]
  4. Graves J. H., McKercher P. D., Farris H. E., Jr, Cowan K. M. Early response of cattle and swine to inactivated foot-and-mouth disease vaccine. Res Vet Sci. 1968 Jan;9(1):35–40. [PubMed] [Google Scholar]
  5. JENKIN C. R., ROWLEY D. The role of opsonins in the clearance of living and inert particles by cells of the reticuloendothelial system. J Exp Med. 1961 Sep 1;114:363–374. doi: 10.1084/jem.114.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MIMS C. A. ASPECTS OF THE PATHOGENESIS OF VIRUS DISEASES. Bacteriol Rev. 1964 Mar;28:30–71. doi: 10.1128/br.28.1.30-71.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MIMS C. A. Rift Valley Fever virus in mice. II. Adsorption and multiplication of virus. Br J Exp Pathol. 1956 Apr;37(2):110–119. [PMC free article] [PubMed] [Google Scholar]
  8. MIMS C. A. Rift Valley Fever virus in mice. III. Further quantitative features of the infective process. Br J Exp Pathol. 1956 Apr;37(2):120–128. [PMC free article] [PubMed] [Google Scholar]
  9. MIMS C. A. The response of mice to large intravenous injections of ectromelia virus. I. The fate of injected virus. Br J Exp Pathol. 1959 Dec;40:533–542. [PMC free article] [PubMed] [Google Scholar]
  10. SCHULTZ I., NEVA F. A. RELATIONSHIP BETWEEN BLOOD CLEARANCE AND VIRURIA AFTER INTRAVENOUS INJECTION OF MICE AND RATS WITH BACTERIOPHAGE AND POLIOVIRUSES. J Immunol. 1965 Jun;94:833–841. [PubMed] [Google Scholar]

Articles from The Journal of Hygiene are provided here courtesy of Cambridge University Press

RESOURCES