Abstract
An epidemic of acute haemorrhagic conjunctivitis (AHC) recurred at Lucknow during July to September 1975, after a gap of 4 years. Out of the 35 cases investigated thoroughly, 20 Entero-70-like cytopathogenic agents were isolated from the conjunctiva which were neutralized by antisera against AHC virus J670/71 of Japan. Seroconversion was seen in 7 out of 11 paired sera from patients. Serological study was also done on 100 sera collected before the AHC epidemic of 1971, 100 sera after 1971 and 100 sera after 1975 epidemic. There were no neutralizing antibodies in the pre-epidemic period, while 18% of sera after the first epidemic and 32% after the second epidemic showed antibodies. The incidence of antibodies was highest (43%) in children aged below 10 years. Of the children born after the first epidemic, 44% had antibodies. Thus our findings show that the AHC virus appeared for the firt time at Lucknow in 1971 and the almost complete absence of disease in children, and its mildness during second epidemic, may be due to immunity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bharucha E. P., Mondkar V. P., Wardia N. H., Irani P. F., Katrak S. M. Neurological complications of a new conjunctivitis. Lancet. 1972 Nov 4;2(7784):970–971. doi: 10.1016/s0140-6736(72)92492-0. [DOI] [PubMed] [Google Scholar]
- Chaturvedi U. C., Mathur A., Singh U. K., Kapoor A. K., Mehrotra R. M., Saxena R. C. An epidemic of picornavirus and adenovirus conjunctivitis. Br J Ophthalmol. 1975 Aug;59(8):439–443. doi: 10.1136/bjo.59.8.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hierholzer J. C., Hilliard K. A., Esposito J. J. Serosurvey for "acute hemorrhagic conjunctivitis" virus (Enterovirus 70) antibodies in the Southeastern United States, with review of the literature and some epidemiologic implications. Am J Epidemiol. 1975 Dec;102(6):533–544. doi: 10.1093/oxfordjournals.aje.a112191. [DOI] [PubMed] [Google Scholar]
- Kono R. Apollo 11 disease or acute hemorrhagic conjunctivitis: a pandemic of a new enterovirus infection of the eyes. Am J Epidemiol. 1975 May;101(5):383–390. doi: 10.1093/oxfordjournals.aje.a112106. [DOI] [PubMed] [Google Scholar]
- Kono R., Sasagawa A., Ishii K., Sugiura S., Ochi M. Pandemic of new type of conjunctivitis. Lancet. 1972 Jun 3;1(7762):1191–1194. doi: 10.1016/s0140-6736(72)90921-x. [DOI] [PubMed] [Google Scholar]
- Kono R., Sasagawa A., Miyamura K., Tajiri E. Serologic characterization and sero-epidemiologic studies on acute hemorrhagic conjunctivitis (AHC) virus. Am J Epidemiol. 1975 May;101(5):444–457. doi: 10.1093/oxfordjournals.aje.a112112. [DOI] [PubMed] [Google Scholar]
- Lim K. H., Yin-Murphy M. Epidemic conjunctivitis in Singapore in 1970 and 1971. Singapore Med J. 1973 Jun;14(2):86–89. [PubMed] [Google Scholar]
- Mirkovic R. R., Kono R., Yin-Murphy M., Sohier R., Schmidt N. J., Melnick J. L. Enterovirus type 70: the etiologic agent of pandemic acute haemorrhagic conjunctivitis. Bull World Health Organ. 1973;49(4):341–346. [PMC free article] [PubMed] [Google Scholar]
- Pramanik D. D. Joy Bangla. An epidemic of conjunctivitis in India. Practitioner. 1971 Dec;207(242):805–806. [PubMed] [Google Scholar]
- Roy I. S., Roy S. N., Ahmed E. Epidemic acute conjunctivitis. Br J Ophthalmol. 1972 Jun;56(6):501–503. doi: 10.1136/bjo.56.6.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wadia N. H., Irani P. F., Katrak S. M. Lumbosacral radiculomyelitis associated with pandemic acute haemorrhagic conjunctivitis. Lancet. 1973 Feb 17;1(7799):350–352. doi: 10.1016/s0140-6736(73)90133-5. [DOI] [PubMed] [Google Scholar]
- Yin-Murphy M. The picornaviruses of epidemic conjunctivitis. Southeast Asian J Trop Med Public Health. 1973 Mar;4(1):11–14. [PubMed] [Google Scholar]