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. 1971 Dec;69(4):571–578. doi: 10.1017/s0022172400021847

Neuraminidase and resistance to vaccination with live influenza A 2 Hong Kong vaccines*

A N Slepushkin, G C Schild, A S Beare, Susan Chinn, D A J Tyrrell
PMCID: PMC2131045  PMID: 5002644

Abstract

Thirty-seven volunteers were inoculated intranasally with living attenuated influenza A2 viruses. Rising titres of circulating antineuraminidase (AN) were detected in 14 of 17 infected volunteers. AN was also found in nasal secretions. Statistical analysis showed that there was a correlation between the titres of haemagglutination-inhibiting antibody (HI) and AN in nasal washings, and between AN in blood and washings. Resistance to infection could be predicted from antibody titres in 29 of 37 volunteers and blood AN alone predicted the outcome of 25 volunteers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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