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. 1938 Jan 1;67(1):25–40. doi: 10.1084/jem.67.1.25

TWO SEROLOGICAL TYPES OF GROUP B HEMOLYTIC STREPTOCOCCI WITH RELATED, BUT NOT IDENTICAL, TYPE-SPECIFIC SUBSTANCES

Rebecca C Lancefield 1
PMCID: PMC2133550  PMID: 19870707

Abstract

1. Among group B hemolytic streptococci one serological type previously described as homogeneous has been shown, instead, to contain two closely related types, distinguishable by reciprocal absorption experiments. These streptococci are designated Types Ia and Ib. 2. Homologous organisms in each case absorb all antibodies from their respective antisera, while organisms of the heterologous related type absorb only the antibody responsible for the cross reactions. Group B streptococci of other types do not absorb the antibodies responsible for the cross reactions between these two related types. The precipitin reaction and passive protection tests in mice were employed in this analysis. 3. The type-specific substance of Type Ia is a polysaccharide. Preliminary study indicates that this is also true of Type Ib. While no data are available concerning the chemical relationships of these substances, it seems probable that the two types elaborate polysaccharides, related chemically as well as serologically.

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Selected References

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  1. Avery O. T. A FURTHER STUDY ON THE BIOLOGIC CLASSIFICATION OF PNEUMOCOCCI. J Exp Med. 1915 Dec 1;22(6):804–819. doi: 10.1084/jem.22.6.804. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Avery O. T., Goebel W. F., Babers F. H. CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : VII. IMMUNOLOGICAL SPECIFICITY OF ANTIGENS PREPARED BY COMBININGalpha- AND beta-GLUCOSIDES OF GLUCOSE WITH PROTEINS. J Exp Med. 1932 Apr 30;55(5):769–780. doi: 10.1084/jem.55.5.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Avery O. T., Goebel W. F. CHEMOIMMUNOLOGICAL STUDIES ON THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : I. THE ISOLATION AND PROPERTIES OF THE ACETYL POLYSACCHARIDE OF PNEUMOCOCCUS TYPE I. J Exp Med. 1933 Nov 30;58(6):731–755. doi: 10.1084/jem.58.6.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Avery O. T., Heidelberger M., Goebel W. F. THE SOLUBLE SPECIFIC SUBSTANCE OF FRIEDLANDER'S BACILLUS : PAPER II. CHEMICAL AND IMMUNOLOGICAL RELATIONSHIPS OF PNEUMOCOCCUS TYPE II AND OF A STRAIN OF FRIEDLANDER'S BACILLUS. J Exp Med. 1925 Oct 31;42(5):709–725. doi: 10.1084/jem.42.5.709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Barnes L. A., Wight E. C. SEROLOGICAL RELATIONSHIP BETWEEN PNEUMOCOCCUS TYPE I AND AN ENCAPSULATED STRAIN OF ESCHERICHIA COLI. J Exp Med. 1935 Jul 31;62(2):281–287. doi: 10.1084/jem.62.2.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bliss E. A. Studies upon Minute Hemolytic Streptococci: III. Serological Differentiation. J Bacteriol. 1937 Jun;33(6):625–642. doi: 10.1128/jb.33.6.625-642.1937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bliss E. A. Studies upon Minute Hemolytic Streptococci: III. Serological Differentiation. J Bacteriol. 1937 Jun;33(6):625–642. doi: 10.1128/jb.33.6.625-642.1937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Castaneda M. R. THE ANTIGENIC RELATIONSHIP BETWEEN BACILLUS PROTEUS X-19 AND RICKETTSIAE : III. A STUDY OF THE ANTIGENIC COMPOSITION OF THE EXTRACTS OF BACILLUS PROTEUS X-19. J Exp Med. 1935 Aug 31;62(3):289–296. doi: 10.1084/jem.62.3.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cooper G., Edwards M., Rosenstein C. THE SEPARATION OF TYPES AMONG THE PNEUMOCOCCI HITHERTO CALLED GROUP IV AND THE DEVELOPMENT OF THERAPEUTIC ANTISERUMS FOR THESE TYPES. J Exp Med. 1929 Feb 28;49(3):461–474. doi: 10.1084/jem.49.3.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Goebel W. F., Babers F. H., Avery O. T. CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : VI. THE SYNTHESIS OFp-AMINOPHENOLalpha-GLUCOSIDE AND ITS COUPLING WITH PROTEIN. J Exp Med. 1932 Apr 30;55(5):761–767. doi: 10.1084/jem.55.5.761. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Harris A. L., Sugg J. Y., Neill J. M. STUDIES ON IMMUNOLOGICAL RELATIONSHIPS AMONG THE PNEUMOCOCCI : II. A COMPARISON OF THE ANTIBODY RESPONSES OF MICE AND OF RABBITS TO IMMUNIZATION WITH TYPICAL TYPE III PNEUMOCOCCI AND TO IMMUNIZATION WITH A RELATED STRAIN. J Exp Med. 1928 May 31;47(6):933–943. doi: 10.1084/jem.47.6.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Heidelberger M., Avery O. T., Goebel W. F. A "SOLUBLE SPECIFIC SUBSTANCE" DERIVED FROM GUM ARABIC. J Exp Med. 1929 Apr 30;49(5):847–857. doi: 10.1084/jem.49.5.847. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Heidelberger M., Kabat E. A., Shrivastava D. L. A QUANTITATIVE STUDY OF THE CROSS REACTION OF TYPES III AND VIII PNEUMOCOCCI IN HORSE AND RABBIT ANTISERA. J Exp Med. 1937 Mar 31;65(4):487–496. doi: 10.1084/jem.65.4.487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Heidelberger M., Kendall F. E. THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : III. A QUANTITATIVE STUDY AND A THEORY OF THE REACTION MECHANISM. J Exp Med. 1935 Mar 31;61(4):563–591. doi: 10.1084/jem.61.4.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lancefield R. C. A SEROLOGICAL DIFFERENTIATION OF SPECIFIC TYPES OF BOVINE HEMOLYTIC STREPTOCOCCI (GROUP B). J Exp Med. 1934 Mar 31;59(4):441–458. doi: 10.1084/jem.59.4.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lancefield R. C., Hare R. THE SEROLOGICAL DIFFERENTIATION OF PATHOGENIC AND NON-PATHOGENIC STRAINS OF HEMOLYTIC STREPTOCOCCI FROM PARTURIENT WOMEN. J Exp Med. 1935 Feb 28;61(3):335–349. doi: 10.1084/jem.61.3.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Landsteiner K., van der Scheer J. ON CROSS REACTIONS OF IMMUNE SERA TO AZOPROTEINS. J Exp Med. 1936 Feb 29;63(3):325–339. doi: 10.1084/jem.63.3.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Miller C. P., Boor A. K. THE CARBOHYDRATES OF GONOCOCCUS AND MENINGOCOCCUS : I. THE ALCOHOL-PRECIPITABLE FRACTION. J Exp Med. 1934 Jan 1;59(1):75–82. doi: 10.1084/jem.59.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sugg J. Y., Gaspari E. L., Fleming W. L., Neill J. M. STUDIES ON IMMUNOLOGICAL RELATIONSHIPS AMONG THE PNEUMOCOCCI : I. A VIRULENT STRAIN OF PNEUMOCOCCUS WHICH Is IMMUNOLOGICALLY RELATED TO, BUT NOT IDENTICAL WITH TYPICAL STRAINS OF TYPE III PNEUMOCOCCI. J Exp Med. 1928 May 31;47(6):917–931. doi: 10.1084/jem.47.6.917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sugg J. Y., Neill J. M. STUDIES ON IMMUNOLOGICAL RELATIONSHIPS AMONG THE PNEUMOCOCCI : V. ANAPHYLAXIS AND PRECIPITATION BETWEEN ANTIGENS AND ANTISERA OF YEAST OF TYPE II PNEUMOCOCCI. J Exp Med. 1931 Mar 31;53(4):527–534. doi: 10.1084/jem.53.4.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sugg J. Y., Richardson L. V., Neill J. M. STUDIES ON IMMUNOLOGICAL RELATIONSHIPS AMONG THE PNEUMOCOCCI : IV. ACTIVE IMMUNIZATION OF MICE AGAINST TYPE II PNEUMOCOCCI BY VACCINATION WITH YEAST. J Exp Med. 1929 Oct 31;50(5):579–581. doi: 10.1084/jem.50.5.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Witebsky E., Neter E., Sobotka H. THE RELATION BETWEEN THE TYPE SPECIFIC CARBOHYDRATES OF PNEUMOCOCCI AND THE BLOOD GROUP SPECIFIC SUBSTANCE A. J Exp Med. 1935 Apr 30;61(5):703–715. doi: 10.1084/jem.61.5.703. [DOI] [PMC free article] [PubMed] [Google Scholar]

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