Abstract
Congenitally athymic (nude) mice accepted for their lifetime intact skin grafts from distantly related mammals (cat, human) and birds (chicken). They also failed to immunologically reject skin grafts from reptiles (lizards) and amphibians (tree frog), although the skin in these grafts underwent varying degrees of disorganization. A definitive role for the thymic defect in this failure to reject xenografts was established by showing that thymus implantation into nude mice enabled them to reject such foreign skin.
Full Text
The Full Text of this article is available as a PDF (473.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Calne R. Y. Organ transplantation between widely disparate species. Transplant Proc. 1970 Dec;2(4):550–556. [PubMed] [Google Scholar]
- Hamilton D. N., Gaugas J. M. Humoral and cellular factors in xenograft rejection by mice. Transplantation. 1972 Jun;13(6):620–622. doi: 10.1097/00007890-197206000-00016. [DOI] [PubMed] [Google Scholar]
- Jooste S. V., Winn H. J., Russell P. S. Destruction of rat skin grafts by humoral antibody. Transplant Proc. 1973 Mar;5(1):713–716. [PubMed] [Google Scholar]
- Kindred B. Immunological unresponsiveness of genetically thymusless (nude) mice. Eur J Immunol. 1971 Jan;1(1):59–61. doi: 10.1002/eji.1830010114. [DOI] [PubMed] [Google Scholar]
- Lance E. M., Levey R. H., Medawar P. B., Ruszkiewicz M. Tolerance of rat skin grafts in adult mice. Proc Natl Acad Sci U S A. 1969 Dec;64(4):1356–1361. doi: 10.1073/pnas.64.4.1356. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lance E. M. Response of mice to xenografts of skin. Transplant Proc. 1970 Dec;2(4):497–505. [PubMed] [Google Scholar]
- Pantelouris E. M. Observations on the immunobiology of 'nude' mice. Immunology. 1971 Feb;20(2):247–252. [PMC free article] [PubMed] [Google Scholar]
- Pennycuik P. R. Unresponsiveness of nude mice to skin allografts. Transplantation. 1971 Apr;11(4):417–418. doi: 10.1097/00007890-197104000-00012. [DOI] [PubMed] [Google Scholar]
- Reed N. D., Manning D. D. Long-term maintenance of normal human skin on congenitally athymic (nude) mice. Proc Soc Exp Biol Med. 1973 Jun;143(2):350–353. doi: 10.3181/00379727-143-37318. [DOI] [PubMed] [Google Scholar]
- Rygaard J. Immunobiology of the mouse mutant "Nude". Preliminary investigations. Acta Pathol Microbiol Scand. 1969;77(4):761–762. [PubMed] [Google Scholar]
- Shaffer C. F., Reed N. D., Jutila J. W. Comparative survival of skin grafts from several donor species on congenitally athymic mice. Transplant Proc. 1973 Mar;5(1):711–712. [PubMed] [Google Scholar]
- Steinmuller D. Cross-species transplantation in embryonic and neonatal animals. Transplant Proc. 1970 Dec;2(4):438–445. [PubMed] [Google Scholar]
- Winn H. J., Baldamus C. A., Jooste S. V., Russell P. S. Acute destruction by humoral antibody of rat skin grafted to mice. J Exp Med. 1973 Apr 1;137(4):893–910. doi: 10.1084/jem.137.4.893. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wortis H. H. Immunological responses of 'nude' mice. Clin Exp Immunol. 1971 Feb;8(2):305–317. [PMC free article] [PubMed] [Google Scholar]