Abstract
Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes.
Full Text
The Full Text of this article is available as a PDF (692.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Leech J. Immunoglobulin-positive Reed Sternberg cells in Hodgkin's disease. Lancet. 1973 Aug 4;2(7823):265–266. doi: 10.1016/s0140-6736(73)93173-5. [DOI] [PubMed] [Google Scholar]
- Longmire R. L., McMillan R., Yelenosky R., Armstrong S., Lang J. E., Craddock C. G. In vitro splenic IgG synthesis in Hodgkin's disease. N Engl J Med. 1973 Oct 11;289(15):763–767. doi: 10.1056/NEJM197310112891501. [DOI] [PubMed] [Google Scholar]
- Mason T. E., Phifer R. F., Spicer S. S., Swallow R. A., Dreskin R. B. An immunoglobulin-enzyme bridge method for localizing tissue antigens. J Histochem Cytochem. 1969 Sep;17(9):563–569. doi: 10.1177/17.9.563. [DOI] [PubMed] [Google Scholar]
- SPICER S. S. Differentiation of nucleic acids by staining at controlled pH and by a Schiff-methylene blue sequence. Stain Technol. 1961 Nov;36:337–340. doi: 10.3109/10520296109113306. [DOI] [PubMed] [Google Scholar]
- Tindle B. H., Parker J. W., Lukes R. J. "Reed-Sternberg cells" in infectious mononucleosis? Am J Clin Pathol. 1972 Dec;58(6):607–617. doi: 10.1093/ajcp/58.6.607. [DOI] [PubMed] [Google Scholar]