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. 1990 Jul;37(4):194–198.

A clinical trial of long-acting local anesthetics for periodontal surgery.

R J Crout 1, G Koraido 1, P A Moore 1
PMCID: PMC2148673  PMID: 2096742

Abstract

The efficacy of long-acting local anesthetics for anesthesia during periodontal surgery and for analgesia during the immediate postoperative period was evaluated. The rationale for using long-acting local anesthetics such as etidocaine and bupivacaine is that they can provide surgical anesthesia and, because of their long duration, prevent discomfort that may occur for 4-6 hours postoperatively. Two clinical trials were performed. The first enrolled patients requiring bilateral periodontal surgery. Using a matched pair design and double-blind randomized study conditions, 2% lidocaine 1/100,000 epinephrine was compared with 1.5% etidocaine 1/200,000 epinephrine for periodontal surgery. The time until complete recovery and the time until pain onset were found to be longer for the etidocaine surgeries. Postoperative pain appeared more severe, and the need for oral analgesics was greater for the lidocaine surgeries. Surgeons' rating of surgical bleeding was significantly greater for the etidocaine procedures. When matched bilateral surgeries were not available, a second double-blind randomized parallel trial was performed that compared 1.5% etidocaine 1/200,000 epinephrine to 0.5% bupivacaine 1/200,000 epinephrine. No significant differences were seen in the quality of anesthesia, degree of bleeding, or postoperative pain between these two long-acting anesthetics.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Babst C. R., Gilling B. N. Bupivacaine: a review. Anesth Prog. 1978 May-Jun;25(3):87–91. [PMC free article] [PubMed] [Google Scholar]
  2. Dunsky J. L., Moore P. A. Long-acting local anesthetics: a comparison of bupivacaine and etidocaine in endodontics. J Endod. 1984 Sep;10(9):457–460. doi: 10.1016/S0099-2399(84)80270-8. [DOI] [PubMed] [Google Scholar]
  3. Feldmann G., Nordenram A. Marcaine in oral surgery. A clinical comparative study with carbocaine. Acta Anaesthesiol Scand Suppl. 1966;23:409–413. [PubMed] [Google Scholar]
  4. Garcia D. G. Etidocaine--a long-acting anesthetic agent. Review of the literature. Anesth Prog. 1982 Jan-Feb;29(1):12–13. [PMC free article] [PubMed] [Google Scholar]
  5. Giovannitti J. A., Bennett C. R. The effectiveness of 1.5% etidocaine HCl with epinephrine 1:200,000 and 2% lidocaine HCl with epinephrine 1:100,000 in oral surgery: a clinical comparison. J Am Dent Assoc. 1983 Oct;107(4):616–618. doi: 10.14219/jada.archive.1983.0299. [DOI] [PubMed] [Google Scholar]
  6. Hlava G. L., Reinhardt R. A., Kalkwarf K. L. Etidocaine HCl local anesthetic for periodontal flap surgery. J Periodontol. 1984 Jun;55(6):364–367. doi: 10.1902/jop.1984.55.6.364. [DOI] [PubMed] [Google Scholar]
  7. Laskin J. L. Use of etidocaine hydrochloride in oral surgery: a clinical study. J Oral Surg. 1978 Nov;36(11):863–865. [PubMed] [Google Scholar]
  8. Laskin J. L., Wallace W. R., DeLeo B. Use of bupivacaine hydrochloride in oral surgery-a clinical study. J Oral Surg. 1977 Jan;35(1):25–29. [PubMed] [Google Scholar]
  9. Linden E. T., Abrams H., Matheny J., Kaplan A. L., Kopczyk R. A., Jasper S. J., Jr A comparison of postoperative pain experience following periodontal surgery using two local anesthetic agents. J Periodontol. 1986 Oct;57(10):637–642. doi: 10.1902/jop.1986.57.10.637. [DOI] [PubMed] [Google Scholar]
  10. Moore P. A. Clinical pharmacology of opioid analgesics. Dent Clin North Am. 1984 Jul;28(3):389–400. [PubMed] [Google Scholar]
  11. Moore P. A., Dunsky J. L. Bupivacaine anesthesia--a clinical trial for endodontic therapy. Oral Surg Oral Med Oral Pathol. 1983 Feb;55(2):176–179. doi: 10.1016/0030-4220(83)90175-5. [DOI] [PubMed] [Google Scholar]
  12. Moore P. A. Long-acting local anesthetics: a review of clinical efficacy in dentistry. Compendium. 1990 Jan;11(1):22, 24-6, 28-30. [PubMed] [Google Scholar]
  13. Nespeca J. A. Clinical trials with bupivacaine in oral surgery. Oral Surg Oral Med Oral Pathol. 1976 Sep;42(3):301–307. doi: 10.1016/0030-4220(76)90163-8. [DOI] [PubMed] [Google Scholar]
  14. Pricco D. F. An evaluation of bupivacaine for regional nerve block in oral surgery. J Oral Surg. 1977 Feb;35(2):126–129. [PubMed] [Google Scholar]
  15. Sisk A. L. Comparison of etidocaine and lidocaine for control of intra- and post-operative bleeding and pain. J Oral Maxillofac Surg. 1986 Jan;44(1):16–20. doi: 10.1016/0278-2391(86)90009-1. [DOI] [PubMed] [Google Scholar]
  16. Sisk A. L., Dionne R. A., Wirdzek P. R. Evaluation of etidocaine hydrochloride for local anesthesia and postoperative pain control in oral surgery. J Oral Maxillofac Surg. 1984 Feb;42(2):84–88. doi: 10.1016/0278-2391(84)90316-1. [DOI] [PubMed] [Google Scholar]
  17. Sveen K. Effect of the addition of a vasoconstrictor to local anesthetic solution on operative and postoperative bleeding, analgesia and wound healing. Int J Oral Surg. 1979 Aug;8(4):301–306. doi: 10.1016/s0300-9785(79)80052-6. [DOI] [PubMed] [Google Scholar]
  18. Teplitsky P. E., Hablichek C. A., Kushneriuk J. S. A comparison of bupivacaine to lidocaine with respect to duration in the maxilla and mandible. J Can Dent Assoc. 1987 Jun;53(6):475–478. [PubMed] [Google Scholar]
  19. Trieger N., Gillen G. H. Bupivacaine anesthesia and post-operative analgesia in oral surgery. Anesth Prog. 1979 Jan-Feb;26(1):20–23. [PMC free article] [PubMed] [Google Scholar]

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