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. 1987 Jun;8:74–86.

Radiation and chemically induced transformation: free radicals, antioxidants and cancer.

C Borek 1
PMCID: PMC2149458  PMID: 3307877

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barrett J. C., Ts'o P. O. Evidence for the progressive nature of neoplastic transformation in vitro. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3761–3765. doi: 10.1073/pnas.75.8.3761. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Borek C. Epithelial in vitro cell systems in carcinogenesis studies. Ann N Y Acad Sci. 1983;407:284–290. doi: 10.1111/j.1749-6632.1983.tb47833.x. [DOI] [PubMed] [Google Scholar]
  3. Borek C., Guernsey D. L., Ong A., Edelman I. S. Critical role played by thyroid hormone in induction of neoplastic transformation by chemical carcinogens in tissue culture. Proc Natl Acad Sci U S A. 1983 Sep;80(18):5749–5752. doi: 10.1073/pnas.80.18.5749. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Borek C., Guernsey D. L., Ong A., Edelman I. S. Critical role played by thyroid hormone in induction of neoplastic transformation by chemical carcinogens in tissue culture. Proc Natl Acad Sci U S A. 1983 Sep;80(18):5749–5752. doi: 10.1073/pnas.80.18.5749. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Borek C., Hall E. J., Rossi H. H. Malignant transformation in cultured hamster embryo cells produced by X-rays, 460-keV monoenergetic neutrons, and heavy ions. Cancer Res. 1978 Sep;38(9):2997–3005. [PubMed] [Google Scholar]
  6. Borek C., Hall E. J. Transformation of mammalian cells in vitro by low doses of X-rays. Nature. 1973 Jun 22;243(5408):450–453. doi: 10.1038/243450a0. [DOI] [PubMed] [Google Scholar]
  7. Borek C., Hall E. J., Zaider M. X rays may be twice as potent as gamma rays for malignant transformation at low doses. Nature. 1983 Jan 13;301(5896):156–158. doi: 10.1038/301156a0. [DOI] [PubMed] [Google Scholar]
  8. Borek C., Ong A., Mason H. Distinctive transforming genes in x-ray-transformed mammalian cells. Proc Natl Acad Sci U S A. 1987 Feb;84(3):794–798. doi: 10.1073/pnas.84.3.794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Borek C., Ong A., Mason H., Donahue L., Biaglow J. E. Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1490–1494. doi: 10.1073/pnas.83.5.1490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Borek C., Ong A., Mason H. Sodium bisulfite protects against radiogenic and chemically induced transformation in hamster embryo and mouse C3H/10T-1/2 cells. Toxicol Ind Health. 1985 Sep;1(1):69–74. doi: 10.1177/074823378500100107. [DOI] [PubMed] [Google Scholar]
  11. Borek C., Ong A., Rhim J. S. Thyroid hormone modulation of transformation induced by Kirsten murine sarcoma virus. Cancer Res. 1985 Apr;45(4):1702–1706. [PubMed] [Google Scholar]
  12. Borek C., Ong A. The interaction of ionizing radiation and food pyrolysis products in producing oncogenic transformation in vitro. Cancer Lett. 1981 Mar;12(1-2):61–66. doi: 10.1016/0304-3835(81)90038-0. [DOI] [PubMed] [Google Scholar]
  13. Borek C. Radiation oncogenesis in cell culture. Adv Cancer Res. 1982;37:159–232. doi: 10.1016/s0065-230x(08)60884-2. [DOI] [PubMed] [Google Scholar]
  14. Borek C., Sachs L. Cell susceptibility to transformation by x-irradiation and fixation of the transformed state. Proc Natl Acad Sci U S A. 1967 May;57(5):1522–1527. doi: 10.1073/pnas.57.5.1522. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Borek C., Sachs L. In vitro cell transformation by x-irradiation. Nature. 1966 Apr 16;210(5033):276–278. doi: 10.1038/210276a0. [DOI] [PubMed] [Google Scholar]
  16. Borek C., Sachs L. The difference in contact inhibition of cell replication between normal cells and cells transformed by different carcinogens. Proc Natl Acad Sci U S A. 1966 Dec;56(6):1705–1711. doi: 10.1073/pnas.56.6.1705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Borek C., Sachs L. The number of cell generations required to fix the transformed state in X-ray-induced transformation. Proc Natl Acad Sci U S A. 1968 Jan;59(1):83–85. doi: 10.1073/pnas.59.1.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Borek C. The induction and control of radiogenic transformation in vitro: cellular and molecular mechanisms. Pharmacol Ther. 1985;27(1):99–142. doi: 10.1016/0163-7258(85)90066-x. [DOI] [PubMed] [Google Scholar]
  19. Borek C. X-ray induced in vitro neoplastic transformation of human diploid cells. Nature. 1980 Feb 21;283(5749):776–778. doi: 10.1038/283776a0. [DOI] [PubMed] [Google Scholar]
  20. Borek C., Zaider M., Ong A., Mason H., Witz G. Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation. Carcinogenesis. 1986 Sep;7(9):1611–1613. doi: 10.1093/carcin/7.9.1611. [DOI] [PubMed] [Google Scholar]
  21. Cerutti P. A. Prooxidant states and tumor promotion. Science. 1985 Jan 25;227(4685):375–381. doi: 10.1126/science.2981433. [DOI] [PubMed] [Google Scholar]
  22. Guernsey D. L., Borek C., Edelman I. S. Crucial role of thyroid hormone in x-ray-induced neoplastic transformation in cell culture. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5708–5711. doi: 10.1073/pnas.78.9.5708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Guernsey D. L., Ong A., Borek C. Thyroid hormone modulation of X ray-induced in vitro neoplastic transformation. Nature. 1980 Dec 11;288(5791):591–592. doi: 10.1038/288591a0. [DOI] [PubMed] [Google Scholar]
  24. Guerrero I., Calzada P., Mayer A., Pellicer A. A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proc Natl Acad Sci U S A. 1984 Jan;81(1):202–205. doi: 10.1073/pnas.81.1.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Hsiao W. L., Gattoni-Celli S., Weinstein I. B. Oncogene-induced transformation of C3H 10T1/2 cells is enhanced by tumor promoters. Science. 1984 Nov 2;226(4674):552–555. doi: 10.1126/science.6436974. [DOI] [PubMed] [Google Scholar]
  26. Miller R., Hall E. J. X-ray dose fractionation and oncogenic transformations in cultured mouse embryo cells. Nature. 1978 Mar 2;272(5648):58–60. doi: 10.1038/272058a0. [DOI] [PubMed] [Google Scholar]
  27. Nakano S., Ts'o P. O. Cellular differentiation and neoplasia: characterization of subpopulations of cells that have neoplasia-related growth properties in Syrian hamster embryo cell cultures. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4995–4999. doi: 10.1073/pnas.78.8.4995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Niki E., Saito T., Kawakami A., Kamiya Y. Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C. J Biol Chem. 1984 Apr 10;259(7):4177–4182. [PubMed] [Google Scholar]
  29. PUCK T. T., MARCUS P. I. Action of x-rays on mammalian cells. J Exp Med. 1956 May 1;103(5):653–666. doi: 10.1084/jem.103.5.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Packer J. E., Slater T. F., Willson R. L. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature. 1979 Apr 19;278(5706):737–738. doi: 10.1038/278737a0. [DOI] [PubMed] [Google Scholar]
  31. Reddy E. P., Reynolds R. K., Santos E., Barbacid M. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature. 1982 Nov 11;300(5888):149–152. doi: 10.1038/300149a0. [DOI] [PubMed] [Google Scholar]
  32. Shamberger R. J., Andreone T. L., Willis C. E. Antioxidants and cancer. IV. Initiating activity of malonaldehyde as a carcinogen. J Natl Cancer Inst. 1974 Dec;53(6):1771–1773. [PubMed] [Google Scholar]
  33. Shilo B. Z., Weinberg R. A. Unique transforming gene in carcinogen-transformed mouse cells. Nature. 1981 Feb 12;289(5798):607–609. doi: 10.1038/289607a0. [DOI] [PubMed] [Google Scholar]
  34. Terzaghi M., Little J. B. X-radiation-induced transformation in a C3H mouse embryo-derived cell line. Cancer Res. 1976 Apr;36(4):1367–1374. [PubMed] [Google Scholar]
  35. Wigler M., Pellicer A., Silverstein S., Axel R. Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell. 1978 Jul;14(3):725–731. doi: 10.1016/0092-8674(78)90254-4. [DOI] [PubMed] [Google Scholar]

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