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. 1981 Apr;146(1):117–120. doi: 10.1128/jb.146.1.117-120.1981

Temperature- and cyclic nucleotide-induced phase transitions of Histoplasma capsulatum.

M Sacco, B Maresca, B V Kumar, G S Kobayashi, G Medoff
PMCID: PMC217059  PMID: 6260737

Abstract

The transition from yeast to mycelia of Histoplasma capsulatum could be accomplished by shifting the temperature of incubation from 37 to 25 degrees C. It was accompanied by many changes in cellular metabolism, including changes in respiration, intracellular cyclic adenosine 3',5'-monophosphate (cAMP) levels, and activities of two enzymes specific for the yeast phase, cystine reductase (EC 1.6.4.1) and cysteine oxidase (EC 1.13.11.20). Even at 37 degrees C, the yeast to mycelial transition could be induced by cAMP and agents which raise the intracellular levels of cAMP (theophylline, acetylsalicylic acid, prostaglandin E1, and nerve growth factor). During this morphogenesis the same pattern of changes occurred as in the temperature-induced transition. Therefore, these changes were not simply dependent on a shift in temperature, but rather were part of the process of the phase transition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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