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. 1981 Feb;145(2):722–728. doi: 10.1128/jb.145.2.722-728.1981

Catabolite repression of Escherichia coli heat-stable enterotoxin activity.

M G Martínez-Cadena, L M Guzman-Verduzco, H Stieglitz, Y M Kupersztoch-Portnoy
PMCID: PMC217171  PMID: 7007347

Abstract

The Escherichia coli heat-stable enterotoxin (ST) coded for by plasmid pYK007 (Apr ST+) showed a dependence for cyclic adenosine 3',5'-monophosphate (cAMP) to express ST activity in an adenyl cyclase (cya) deletion mutant; no ST activity was detected in the presence of cAMP in a cAMP receptor protein (crp) deletion mutant or in a double deletion mutant (delta cya delta crp). The cya-crp effect on ST activity could not be accounted for by a modification of the copy number of plasmid deoxyribonucleic acid per chromosome equivalent or by an alteration in the secretion of an active intracellular enterotoxin.

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Selected References

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