Abstract
2-Amino-5-ethoxycarbonylpyrimidine-4(3H)-one, a pyrimidine analog, inhibited growth of Bacillus subtilis. Data were obtained which suggested that the analog interfered with the methylation process. A mutant resistant to the inhibitor was isolated, and the mutation was mapped.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DAVIS B. D., MINGIOLI E. S. Mutants of Escherichia coli requiring methionine or vitamin B12. J Bacteriol. 1950 Jul;60(1):17–28. doi: 10.1128/jb.60.1.17-28.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gibson F., Pittard J. Pathways of biosynthesis of aromatic amino acids and vitamins and their control in microorganisms. Bacteriol Rev. 1968 Dec;32(4 Pt 2):465–492. [PMC free article] [PubMed] [Google Scholar]
- Hoch J. A., Barat M., Anagnostopoulos C. Transformation and transduction in recombination-defective mutants of Bacillus subtilis. J Bacteriol. 1967 Jun;93(6):1925–1937. doi: 10.1128/jb.93.6.1925-1937.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoch S. O. Mapping of the 5-methyltryptophan resistance locus in Bacillus subtilis. J Bacteriol. 1974 Jan;117(1):315–317. doi: 10.1128/jb.117.1.315-317.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holtzclaw W. D., Chapman L. F. Properties of some norvaline-resistant mutants of Bacillus subtilis. J Gen Microbiol. 1975 Jun;88(2):289–294. doi: 10.1099/00221287-88-2-289. [DOI] [PubMed] [Google Scholar]
- Jones P. A., Taylor S. M. Cellular differentiation, cytidine analogs and DNA methylation. Cell. 1980 May;20(1):85–93. doi: 10.1016/0092-8674(80)90237-8. [DOI] [PubMed] [Google Scholar]
- NESTER E. W., LEDERBERG J. Linkage of genetic units of Bacillus subtilis in DNA transformation. Proc Natl Acad Sci U S A. 1961 Jan 15;47:52–55. doi: 10.1073/pnas.47.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Umbarger H. E. Metabolite analogs as genetic and biochemical probes. Adv Genet. 1971;16:119–140. doi: 10.1016/s0065-2660(08)60356-9. [DOI] [PubMed] [Google Scholar]