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. 1980 Aug 1;152(2):350–360. doi: 10.1084/jem.152.2.350

Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation

PMCID: PMC2185951  PMID: 6967513

Abstract

Cell-cell interactions between mature T cells and peripheral blood null cells induce erythropoietin-stimulated differentiation of peripheral blood-derived erythroid progenitors. By the use of complement-fixing cytolytic murine hybridoma and antibody uniquely reactive with mature T lymphocytes, this dependence of immature peripheral blood erythroid burst-forming unit (BFU-E) differentiation upon mature T cells or a T cell conditioned medium is confirmed. By using the same antibody, it is demonstrated that the differentiation of mature bone marrow BFU-E does not require either mature T cells or lymphocyte mitogenic factor. These findings do not preclude the presence in the bone marrow of other cells, perhaps even immature T cells, that influence erythropoietin- dependent erythroid differentiation of mature marrow BFU-E.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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