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. 1985 Apr;162(1):448–450. doi: 10.1128/jb.162.1.448-450.1985

Glutathione reductase is not required for maintenance of reduced glutathione in Escherichia coli K-12.

C K Tuggle, J A Fuchs
PMCID: PMC219012  PMID: 3884598

Abstract

Seven independently isolated glutathione reductase-deficient (gor) Escherichia coli mutants were found to have an in vivo glutathione redox state that did not significantly differ from that of the parental strain, 98 to 99% reduced. Strains containing both a gor mutation and either a trxA mutation (thioredoxin deficient) or a trxB mutation (thioredoxin reductase deficient) were able to maintain a 94 to 96% reduced glutathione pool, suggesting that glutathione can be reduced independently of glutathione reductase and thioredoxin reductase.

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Selected References

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