Abstract
46% of sera from 30 children with rheumatic chorea showed IgG antibody reacting with neuronal cytoplasm of human caudate and subthalamic nuclei. The antibody was also detected in 14% of 50 children with active rheumatic carditis. 55 normal control sera, as well as 148 sera from a broad variety of other disease states showed a low prevalence (1.8-4.0%) of positive reactions. In rheumatic chorea the presence of anti-neuronal antibody appeared to correlate with severity and duration of clinical attacks. Antibody reacting with neuronal cytoplasm was completely removed by absorption with Group A streptococcal membranes or with isolated human neurons from caudate nucleus. Partial absorption of antibody was also recorded using Group A cell wall preparations but not with Group A carbohydrate. No absorption of positive reactions was seen with streptococcal Group D membranes or cell walls. In rheumatic chorea, anti-neuronal antibody appeared to represent cross-reaction with antigens shared by Group A streptococcal membranes.
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- Aminoff M. J., Trenchard A., Turner P., Wood W. G., Hills M. Plasma uptake of dopamine and 5-hydroxytryptamine and plasma-catecholamine levels in patients with Huntington's chorea. Lancet. 1974 Nov 9;2(7889):1115–1116. doi: 10.1016/s0140-6736(74)90873-3. [DOI] [PubMed] [Google Scholar]
- Fischetti V. A., Gotschlich E. C., Bernheimer A. W. Purification and physical properties of group C streptococcal phage-associated lysin. J Exp Med. 1971 May 1;133(5):1105–1117. doi: 10.1084/jem.133.5.1105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldstein I., Rebeyrotte P., Parlebas J., Halpern B. Isolation from heart valves of glycopeptides which share immunological properties with Streptococcus haemolyticus group A polysaccharides. Nature. 1968 Aug 24;219(5156):866–868. doi: 10.1038/219866a0. [DOI] [PubMed] [Google Scholar]
- Husby G., Blomhoff J. P., Skrede S., Elgjo K., Gjone E. Detection of immunoglobulins in paraffin-embedded liver biopsies. Studies in 100 patients with special regard to immunological findings in active chronic hepatitis. Scand J Gastroenterol. 1973;8(7):621–629. [PubMed] [Google Scholar]
- Husby G., Strickland R. G., Caldwell J. L., Williams R. C., Jr Localization of T and B cells and alpha fetoprotein in hepatic biopsies from patients with liver disease. J Clin Invest. 1975 Nov;56(5):1198–1209. doi: 10.1172/JCI108197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAPLAN M. H. IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE. J Immunol. 1963 Apr;90:595–606. [PubMed] [Google Scholar]
- KAPLAN M. H., SVEC K. H. IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. III. PRESENCE IN HUMAN SERA OF STREPTOCOCCAL ANTIBODY CROSS-REACTIVE WITH HEART TISSUE. ASSOCIATION WITH STREPTOCOCCAL INFECTION, RHEUMATIC FEVER, AND GLOMERULONEPHRITIS. J Exp Med. 1964 Apr 1;119:651–666. doi: 10.1084/jem.119.4.651. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kawakita S., Iwamoto H. Studies on the pathogenesis of rheumatic heart disease. An immunological relationship between the polysaccharide of group A streptococcus and the glycoprotein of heart valve. Jpn Circ J. 1975 Apr;39(4):439–446. doi: 10.1253/jcj.39.439. [DOI] [PubMed] [Google Scholar]
- Kingston D., Glynn L. E. A cross-reaction between Str. pyogenes and human fibroblasts, endothelial cells and astrocytes. Immunology. 1971 Dec;21(6):1003–1016. [PMC free article] [PubMed] [Google Scholar]
- Kingston D., Glynn L. E. Anti-streptococcal antibodies reacting with brain tissue. I. Immunofluourescent studies. Br J Exp Pathol. 1976 Feb;57(1):114–128. [PMC free article] [PubMed] [Google Scholar]
- MARKOWITZ A. S., LANGE C. F., Jr STREPTOCOCCAL RELATED GLOMERULONEPHRITIS. I. ISOLATION, IMMUNOCHEMISTRY AND COMPARATIVE CHEMISTRY OF SOLUBLE FRACTIONS FROM TYPE 12 NEPHRITOGENIC STREPTOCOCCI AND HUMAN GLOMERULI. J Immunol. 1964 Apr;92:565–575. [PubMed] [Google Scholar]
- Moskowitz M. A., Wurtman R. J. Catecholamines and neurologic diseases (first of two parts). N Engl J Med. 1975 Aug 7;293(6):274–280. doi: 10.1056/NEJM197508072930605. [DOI] [PubMed] [Google Scholar]
- Roy S. B. Proceedings: Epidemiological study of rheumatic fever and rheumatic heart disease in India. Jpn Circ J. 1975 Feb;39(2):188–189. [PubMed] [Google Scholar]
- Sellinger O. Z., Azcurra J. M., Johnson D. E., Ohlsson W. G., Lodin Z. Independence of protein synthesis and drug uptake in nerve cell bodies and glial cells isolated by a new technique. Nat New Biol. 1971 Apr 21;230(16):253–256. doi: 10.1038/newbio230253a0. [DOI] [PubMed] [Google Scholar]
- Vandvik B., Norrby E. Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1060–1063. doi: 10.1073/pnas.70.4.1060. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zabriskie J. B., Freimer E. H. An immunological relationship between the group. A streptococcus and mammalian muscle. J Exp Med. 1966 Oct 1;124(4):661–678. doi: 10.1084/jem.124.4.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zabriskie J. B., Hsu K. C., Seegal B. C. Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance. Clin Exp Immunol. 1970 Aug;7(2):147–159. [PMC free article] [PubMed] [Google Scholar]
- Zabriskie J. B. Mimetic relationships between group A streptococci and mammalian tissues. Adv Immunol. 1967;7:147–188. doi: 10.1016/s0065-2776(08)60128-5. [DOI] [PubMed] [Google Scholar]